Vagina
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This article addresses the basics of vagina, from a pathologic perspective.
Low grade pre-cancerous lesions of the vagina (VAIN) are typically HPV positive, while high grade pre-cancerous lesions and cancer are less often HPV positive.[1]
Normal
- Squamous epithelium, non-keratinized.
Prolapse
- Pieces of vagina are often submitted in the context of uterine prolapse.
Microscopic
- Squamous epithelium - may be keratinized.
Vaginal cysts
- Most common is vaginal inclusion cyst.[2]
- Usually due to trauma.
Vaginal cancer
- Squamous cell carcinoma - most common cancer of the vagina.
- Precursor lesions are similar to the cervix[3] and are often HPV associated - see vaginal intraepithelial neoplasia (VAIN).
- Development of VAIN can be associated with cervical intraepithelial neoplasia and arises in up to 7.4% of patients that underwent a (total) hysterectomy for CIN2 or worse.[4]
- Precursor lesions are similar to the cervix[3] and are often HPV associated - see vaginal intraepithelial neoplasia (VAIN).
- Malignant melanoma - rare.
Images:
Vaginal intraepithelial neoplasia
- Abbreviated VAIN.
General
VAIN is graded like cervical lesions:
- Mild vaginal intraepithelial neoplasia (VAIN I).
- Moderate vaginal intraepithelial neoplasia (VAIN II).
- Severe vaginal intraepithelial neoplasia (VAIN III).
Viral infections
General
- Cannot differentiate HSV1, HSV2, VZV using H&E.[5]
Microscopic
Features:[5]
- Keratinocytes enlargement + acanthosis.
- Intraepidermal vesicles & bullae.
- Nuclear changes - 3 Ms:
- Moulding of nuclei.
- Margination of chromatin.
- Multinucleation.
- Nuclei have "steel gray" colour.
Images:
See also
- Gynecologic pathology.
- Uterus.
- Cervix - cervical intraepithelial neoplasia.
- Anus - anal intraepithelial neoplasia.
- Vulva.
References
- ↑ De Vuyst H, Clifford GM, Nascimento MC, Madeleine MM, Franceschi S (April 2009). "Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: a meta-analysis". Int. J. Cancer 124 (7): 1626–36. doi:10.1002/ijc.24116. PMID 19115209.
- ↑ URL: http://www.nlm.nih.gov/medlineplus/ency/article/001509.htm. Accessed on: 6 July 2010.
- ↑ Indraccolo U, Chiocci L, Baldoni A (2008). "Does vaginal intraepithelial neoplasia have the same evolution as cervical intraepithelial neoplasia?". Eur. J. Gynaecol. Oncol. 29 (4): 371–3. PMID 18714572.
- ↑ Schockaert S, Poppe W, Arbyn M, Verguts T, Verguts J (August 2008). "Incidence of vaginal intraepithelial neoplasia after hysterectomy for cervical intraepithelial neoplasia: a retrospective study". Am. J. Obstet. Gynecol. 199 (2): 113.e1–5. doi:10.1016/j.ajog.2008.02.026. PMID 18456229.
- ↑ 5.0 5.1 URL: http://missinglink.ucsf.edu/lm/DermatologyGlossary/herpes_simplex.html. Accessed on: 30 August 2011.