Scleroderma

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Scleroderma is a disease that keeps rheumatologists busy.

General

Clinical:

  • Anti-centromere antibody (ACA) +ve.
    • Common in limited systemic scleroderma, AKA CREST syndrome.
  • Scl-70 (topoisomerase I) +ve.
    • Common in diffuse scleroderma.

CREST syndrome:

  • Calcinosis.
  • Raynaud's phenomenon.
  • Esophageal dysmotility.
  • Sclerodactyly.
  • Telangiectasia.

Associated pathology

See also