Lipofuscin
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Lipofuscin is benign pigment that can be confused for melanin. It is also known as age pigment, as it as associated strongly with aging.[1]
Called "melanosis" when it is really lipofuscin
- Bladder lipofuscin pigmentation.[2]
- Pseudomelanosis coli also known as "melanosis coli".[3]
Microscopic
Features:
- Brown pigment.
DDx:
- Melanin.
- Iron.
- Bile.
- Exogenous pigment.
Stains
Features:
- PAS stain +ve.[1]
- Melanin stain -ve.
See also
References
- ↑ 1.0 1.1 Porta EA (April 2002). "Pigments in aging: an overview". Ann. N. Y. Acad. Sci. 959: 57–65. doi:10.1111/j.1749-6632.2002.tb02083.x. PMID 11976186.
- ↑ Atieh M, McIntire PJ, Kilic I, Picken MM, Flanigan RC, Barkan GA, Pambuccian SE (September 2019). "Lipofuscin pigmentation (so called "melanosis") of the bladder". Diagn. Cytopathol. 47 (9): 968–971. doi:10.1002/dc.24204. PMID 31148387.
- ↑ Freeman HJ (July 2008). ""Melanosis" in the small and large intestine". World J. Gastroenterol. 14 (27): 4296-9. PMID 18666316. http://www.wjgnet.com/1007-9327/14/4296.asp.