Squamous metaplasia of the rectum/anus
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Squamous metaplasia of the anus is a metaplastic change of the columnar epithelium. It can histologically mimic anal intraepithelial neoplasia (AIN), especially. high-grade squamous intraepithelial lesion (HSIL).
Images
IHC
- p16 -ve
- Usually weak-to-moderate patchy, not full thickness.
- Ki-67 - scattered cells positive.