Sarcoidosis

Sarcoidosis is non-necrotizing granulomatous disease of unknown etiology. It classically associated with (pulmonary) hilar lymphadenopathy. It may be found in almost any organ, e.g. heart, appendix.

General

• Diagnosis of exclusion - infection must be excluded.
• Radiologic differential diagnosis includes carcinomatosis.

Microscopic

Features:

• Granulomata, well-formed, non-necrotizing.
  • Negative for microorganisms with special stains (PAS-D, GMS, AFB).
  • Granulomata - interstitial location.

Image(s):

• Sarcoidosis - lung (WC).
• Granulomata in sarcoidosis with asteroid bodies (WC).

See also

• Medical lung diseases.
• Heart.