Clear cell acanthoma
Clear cell acanthoma, abbreviated CCA, a benign skin lesion classically found on the leg.
General
- Benign.
- Elderly.
- Classically on the leg.[1]
- Rare.
- Clinically not distinct.
- Suspected clinically in only ~3% of cases.[2]
Microscopic
Features:[3]
- Psoriasiform pattern - epidermal thickening (acanthosis).
- Keratinocytes:
- Pale or light pink cytoplasm (when compared to surrounding non-lesional keratinocytes).
- Separated from one another (spongiosis).
- +/-Stratum corneum neutrophils.
DDx:
Images
See also
References
- ↑ Akin, FY.; Ertam, I.; Ceylan, C.; Kazandi, A.; Ozdemir, F.. "Clear cell acanthoma: new observations on dermatoscopy.". Indian J Dermatol Venereol Leprol 74 (3): 285-7. PMID 18583817.
- ↑ Morrison, LK.; Duffey, M.; Janik, M.; Shamma, HN. (Sep 2010). "Clear cell acanthoma: a rare clinical diagnosis prior to biopsy.". Int J Dermatol 49 (9): 1008-11. PMID 20931670.
- ↑ URL: http://www.drmihm.com/cases/case.cfm?CaseID=45. Accessed on: 7 February 2012.