Giant cell cystitis
Giant cell cystitis is term used for a benign change of the mesenchymal cells of the urinary bladder lamina propria.
Giant cell cystitis is considered a misnomer as may be seen in an otherwise normal bladder.[1]
General
- Considered a common benign finding; not a clinical entity.[2]
Microscopic
Features:[3]
- Scattered atypical mesenchymal cells - mononuclear or multinucleated.
- +/-Nuclear hyperchromasia and/or lobulation.
- Absence of apparent mitotic activity.
DDx:
- Radiation cystitis - history of radiation, more atypical usually with nucleoli.[2]
- Sarcoma of the bladder or metastatic sarcoma - typically more cellular.[2]
- Sarcomatoid change in urothelial carcinoma.
See also
References
- ↑ Hameed, O.; Humphrey, PA. (Mar 2010). "Pseudoneoplastic mimics of prostate and bladder carcinomas.". Arch Pathol Lab Med 134 (3): 427-43. doi:10.1043/1543-2165-134.3.427. PMID 20196670.
- ↑ 2.0 2.1 2.2 Amin, Mahul B. (2010). Diagnostic Pathology: Genitourinary (1st ed.). Amirsys. pp. 2:6. ISBN 978-1931884280.
- ↑ Amin, Mahul B.; Eble, John; Grignon, David; Srigley, John. (2013). Urological Pathology (1st ed.). Wolters Kluwer. pp. 305. ISBN 978-0781782814.