Lymphoepithelioma-like carcinoma of the urinary bladder

From Libre Pathology
Revision as of 20:14, 5 September 2015 by Michael (talk | contribs)
Jump to navigation Jump to search

Lymphoepithelioma-like carcinoma of the urinary bladder, also urinary bladder lymphoepithelioma-like carcinoma (abbreviated UBLELC), is a rare variant of urothelial carcinoma.[1]

Lymphoepithelioma-like carcinoma of the urinary bladder
Diagnosis in short

Urinary bladder lymphoepithelioma-like carcinoma. H&E stain.
LM squamoid cells with abundant dense cytoplasm central nuclei +/- small/indistinct nucleoli, prominent lymphoid infiltrate
Subtypes subtype of urothelial carcinoma
LM DDx lymphoma, urothelial carcinoma and inflammation, metastatic lymphoepithelioma-like carcinoma
Site urinary bladder - see urothelium
Prevalence rare
Other not associated with EBV

General

  • Rare.
  • Not associated with EBV.[2]

Microscopic

Features:

  • Clusters of (cohesive) squamoid cells with:
    • Abundant dense cytoplasm.
    • Central nuclei +/- small/indistinct nucleoli.
    • Surrounded by a prominent lymphoid component - key feature.

DDx:

Images

  • UBLELC - low mag. (WC)

  • UBLELC - intermed. mag. (WC)

  • UBLELC - intermed. mag. (WC)

  • UBLELC - high mag. (WC)

  • UBLELC - very high mag. (WC)

www:

See also

References

  1. ↑ Amin, MB. (Jun 2009). "Histological variants of urothelial carcinoma: diagnostic, therapeutic and prognostic implications.". Mod Pathol 22 Suppl 2: S96-S118. doi:10.1038/modpathol.2009.26. PMID 19494856.
  2. ↑ Williamson, SR.; Zhang, S.; Lopez-Beltran, A.; Shah, RB.; Montironi, R.; Tan, PH.; Wang, M.; Baldridge, LA. et al. (Apr 2011). "Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features.". Am J Surg Pathol 35 (4): 474-83. doi:10.1097/PAS.0b013e31820f709e. PMID 21383609.
  3. ↑ 3.0 3.1 Singh, NG.; Mannan, AA.; Rifaat, AA.; Kahvic, M.. "Lymphoepithelioma-like carcinoma of the urinary bladder: report of a rare case.". Ann Saudi Med 29 (6): 478-81. doi:10.4103/0256-4947.57173. PMID 19847088.
Retrieved from "https://librepathology.org/w/index.php?title=Lymphoepithelioma-like_carcinoma_of_the_urinary_bladder&oldid=39600"