Dysembryoplastic neuroepithelial tumour

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Dysembryoplastic neuroepithelial tumour, abbreviated DNT, is a rare neuropathology tumour that is associated with epilepsy.

General

  • Common tumour cause of drug resistant epilepsy.[1]
  • Paediatric population.

Gross/radiology

  • Temporal lobe.
  • Variable architecture:[2] cystic, solitary nodular, multinodular.

Microscopic

Features:[2]

  • Cells similar to oligodendrocytes:
    • Large central nuclei with indentations.
    • Multiple small nucleoli (common).
    • Clear cytoplasm.

DDx:

Images

www:

See also

References

  1. Cataltepe, O.; Turanli, G.; Yalnizoglu, D.; Topçu, M.; Akalan, N. (Apr 2005). "Surgical management of temporal lobe tumor-related epilepsy in children.". J Neurosurg 102 (3 Suppl): 280-7. doi:10.3171/ped.2005.102.3.0280. PMID 15881751.
  2. 2.0 2.1 2.2 O'Brien, DF.; Farrell, M.; Delanty, N.; Traunecker, H.; Perrin, R.; Smyth, MD.; Park, TS. (Dec 2007). "The Children's Cancer and Leukaemia Group guidelines for the diagnosis and management of dysembryoplastic neuroepithelial tumours.". Br J Neurosurg 21 (6): 539-49. doi:10.1080/02688690701594817. PMID 18071981.