Metaphyseal fibrous defect

Template:Metaphyseal fibrous defect
	Diagnosis in short
Synonyms	Nonossifying fibroma
Clinical history	Incidental radiograhic finding
Radiology	Lucent defect

General

Common
Non-neoplastic
Self-limited
Skeletally immature individuals, children and adolescent
Often small lesions discovered an radiographic incidentaloma

Synonyms

Nonossifying fibroma (larger but otherwise identical)
Fibrous cortical defect
Fibrous metaphyseal defect
Fibroxanthoma of bone

Site

Metaphysis of distal femur or proximal tibia (80%)
Cortical
Metaphysis
Long bones
Eccentric location

Gross

Firm, granular, brown to yellow to red

Microscopic

Spindle cells without cytologic atypia are arranged in a storiform pattern with scattered chronic inflammatory cells and benign giant cells. Foam cells and hemosiderin deposition are present. Mitoses are seen but cytologic atypia is absent.

Differential Diagnosis

Giant cell tumor of bone (epiphyseal location, occurs in adults)

Relevant Diagnostic Groups

FOG MACHINES - acronym for radiographically lytic bone lesions Cite error: Invalid <ref> tag; invalid names, e.g. too many

Clinical history

Incidental radiographic finding
Pathologic fracture

Radiographic findings

Sharply demarcated, lucent, loculated, meta-diaphyseal lesion surrounded by a rim of sclerotic bone

Sign out

BONE; CURETTAGE: METAPHYSEAL FIBROUS DEFECT.

References