Lymphoepithelioma-like carcinoma

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Lymphoepithelioma-like carcinoma, abbreviated LELC, is a very rare, poorly differentiated, malignant epithelial tumour.

It can be considered a subtype of squamous carcinoma (AKA squamous cell carcinoma);[1] however, some advocate it be considered a separate entity.[2]

General

It is thought to be related to nasopharyngeal carcinoma (AKA lymphoepithelioma).[3][4]


Epidemiology:

  • Common in Inuit and some Asians.[5]


Etiology:

  • Associated with EBV,[3] in most anatomical sites (nasopharynx, stomach, lung, thymus, salivary gland); the skin and uterine cervix appear to be exceptions.[6]
    • The exception to the exception: there is a case report of EBV in LELC of the skin.[7]


Notes:

  • The (macroscopic, microscopic, epidemiologic, prognostic) features of LELC are very similar to medullary carcinoma -- EBV status is one differentiator.[6]

Microscopic

Features:

  • Clusters of cohesive squamoid cells with:
    • Abundant dense cytoplasm.
    • Central nuclei +/- small/indistinct nucleoli.
    • Surrounded by a prominent lymphoid component - key feature.

DDx:

Images

  • LELC - low mag. (WC)

  • LELC - high mag. (WC)

www:

See also

References

  1. ↑ URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970297-2#back-bib45. Accessed on: 26 May 2011.
  2. ↑ Skinner, NE.; Horowitz, RI.; Majmudar, B. (Oct 2000). "Lymphoepithelioma-like carcinoma of the uterine cervix.". South Med J 93 (10): 1024-7. PMID 11147469.
  3. ↑ 3.0 3.1 Mayer, EK.; Beckley, I.; Winkler, MH. (Mar 2007). "Lymphoepithelioma-like carcinoma of the urinary bladder--diagnostic and clinical implications.". Nat Clin Pract Urol 4 (3): 167-71. doi:10.1038/ncpuro0725. PMID 17347662.
  4. ↑ 4.0 4.1 URL: http://dermatology.cdlib.org/148/case_presentations/lymphoepithelioma/arsenovic.html. Accessed on: 11 May 2011.
  5. ↑ URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970335-7. Accessed on: 11 May 2011.
  6. ↑ 6.0 6.1 Lespagnard, L.; Cochaux, P.; Larsimont, D.; Degeyter, M.; Velu, T.; Heimann, R. (Apr 1995). "Absence of Epstein-Barr virus in medullary carcinoma of the breast as demonstrated by immunophenotyping, in situ hybridization and polymerase chain reaction.". Am J Clin Pathol 103 (4): 449-52. PMID 7726142.
  7. ↑ Aoki, R.; Mitsui, H.; Harada, K.; Kawamura, T.; Shibagaki, N.; Tsukamoto, K.; Murata, S.; Shimada, S. (Apr 2010). "A case of lymphoepithelioma-like carcinoma of the skin associated with Epstein-Barr virus infection.". J Am Acad Dermatol 62 (4): 681-4. doi:10.1016/j.jaad.2008.07.024. PMID 20227583.
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