Epstein-Barr virus-associated smooth muscle tumour

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Epstein-Barr virus-associated smooth muscle tumour is a very uncommon soft tissue lesion.[1]

General

Microscopic

Features:[1]

  • Smooth muscle lesion:
    • Spindle cells in a fascicular arrangement.
    • Usually minimal nuclear atypia and few mitoses.
  • Lymphocytes.

DDx:

IHC

  • SMA +ve
  • Desmin +ve/-ve.
  • CD34 -ve.
  • CD117 -ve.

References

  1. ↑ 1.0 1.1 Deyrup, AT.; Lee, VK.; Hill, CE.; Cheuk, W.; Toh, HC.; Kesavan, S.; Chan, EW.; Weiss, SW. (Jan 2006). "Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients.". Am J Surg Pathol 30 (1): 75-82. PMID 16330945.
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