Klinefelter syndrome

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Klinefelter syndrome, abbreviated KS, is a common genetic abnormality in men.

Prevalence

Characteristics

Mnemonic Mr KLINE FELT Some Guys:[2]

  • Male phenotype.
  • Karyotype usu. 47,XXY
  • Long/tall.
  • Infertile.
  • Nondisjunction of sex chromosomes.
  • Eunuchoid body proportions.
  • FSH elevated, minimal Facial & axillary hair.
  • Estradiol/testosterone ratio elevation.
  • LH elevated, Leukemias risk increase (AML), Learning disability.
  • Testosterone low.
  • Small penis & testis.
  • Gynecomastia.

References

  1. ↑ Vignozzi, L.; Corona, G.; Forti, G.; Jannini, EA.; Maggi, M. (Jun 2010). "Clinical and therapeutic aspects of Klinefelter's syndrome: sexual function.". Mol Hum Reprod 16 (6): 418-24. doi:10.1093/molehr/gaq022. PMID 20348547.
  2. ↑ URL: http://www.lifehugger.com/moc/2840/Klinefelters_syndrome_KS. Accessed on: 27 March 2012.
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