Small cell lymphomas
Revision as of 15:47, 16 August 2010 by Michael (talk | contribs) (→MALT lymphoma/Marginal zone lymphoma)
Small cell lymphomas are a collection of commonly seen lymphomas that have a near-identical histomorphologic appearance.
The group includes:
- Small lymphocytic lymphoma/chronic lymphocytic leukemia.
- Follicular lymphoma.
- Mantle cell lymphoma.
- Marginal zone lymphoma.
- Hairy cell leukemia.
- Immunoproliferative small intestinal disease (IPSID).[1]
Table of B-cell lymphoma
Small cell lymphomas:
| Name | Location | Size of cells | IHC | Translocations | Clinical | Other |
|---|---|---|---|---|---|---|
| Follicular lymphoma | Follicle | Small, centrocytes, centroblasts | CD10+, bcl-6+[2] | t(14,18) | Clinical ? | Other ? |
| Mantle cell lymphoma | Mantle zone | Small | CD5+, CD23-, CD43+, cyclin D1+[2] | t(11;14)(q13;q32)[3] | Clinical ? | Other ? |
| Marginal zone lymphoma (MALT) | Marginal zone | Small | CD21+, CD11c+, CD5-, CD23-[2] | Translocations | Clinical | Other |
| Precursor lymphoblastic lymphoma/leukemia | Location ? | Small | CD10+, CD5-, TdT+, CD99+[2] | Translocations ? | Clinical ? | Other ? |
| Small lymphocytic lymphoma/chronic lymphocytic leukemia | Location ? | Small | CD5+, CD23+, CD43+, cyclin D1- | Translocations ? | Good prognosis | Other ? |
Medium and large cell lymphomas:
| Name | Location | Size of cells | IHC | Translocations | Clinical | Other |
|---|---|---|---|---|---|---|
| Burkitt's lymphoma | Follicle | Large cells | CD10, bcl-6 | t(8;14) (q24;q32) | Rapid growth | "Starry sky" |
| Diffuse large B cell lymphoma | Follicle (?) | Large 4-5X of lymphocyte | MIB-1 >40% | none/like follicular l. | Poor prognosis | Common among lymphomas |
| Name | Location | Size of cells | IHC | Translocations | Clinical | Other |
Follicular lymphoma
General
- A very common type of lymphoma.
- Express BCL2.[4]
Microscopic
Features:
- Abundant abnormal lymphoid follicles.
IHC
Features:[4]
- CD10 +ve/-ve.
- CD5 -ve.
- +ve in mantle cell lymphoma.
- CD23 -ve/+ve.
- +ve in CLL.
- CD43 -ve.
- +ve in mantle cell lymphoma, marginal zone lymphoma.
- CD11c -ve -- flow cytometry only.
Molecular
- t(14;18)(q32;q21)/IGH-BCL2 in 70-95% of cases.[4]
- Should not be confused with t(14;18)(q32;q21)/IGH-MALT1 seen in MALT lymphomas.[5]
Mantle cell lymphoma
General
- Comes in different flavours.
Microscopic
Features:
- See histomorphology of small cell lymphomas.
MALT lymphoma/Marginal zone lymphoma
General
- Abbreviated as MZL.
Classification
- Comes in different flavours:
- Extranodal marginal zone lymphoma.
- Splenic marginal zone lymphoma.
Microscopic
Features:
- See histomorphology of small cell lymphomas.
- "Lymphoepithelial lesion" - gastric crypts invaded by a monomorphous population of lymphocytes.[6]
- Features:
- Cluster of lymphocytes - three cells or more - key feature.
- Single lymphocytes don't count.
- Clearing around the lymphocyte cluster.
- Cluster of lymphocytes - three cells or more - key feature.
- Not specific MALT lymphoma.[7]
- Features:
Hairy cell leukemia
General
- Name comes from appearance on blood smear - cell hairy.
Microscopic
Features:
- See histomorphology of small cell lymphomas.
Images:
Small lymphocytic lymphoma/chronic lymphocytic leukemia
General
- Very common.
- Good prognosis.
Microscopic
Features:
- See histomorphology of small cell lymphomas.
See also
References
- ↑ Al-Saleem T, Al-Mondhiry H (March 2005). "Immunoproliferative small intestinal disease (IPSID): a model for mature B-cell neoplasms". Blood 105 (6): 2274–80. doi:10.1182/blood-2004-07-2755. PMID 15542584. http://bloodjournal.hematologylibrary.org/cgi/content/long/105/6/2274.>
- ↑ 2.0 2.1 2.2 2.3 Lester, Susan Carole (2005). Manual of Surgical Pathology (2nd ed.). Saunders. pp. 95. ISBN 978-0443066450.
- ↑ URL: http://atlasgeneticsoncology.org/Anomalies/t1114ID2021.html. Accessed on: 10 August 2010.
- ↑ 4.0 4.1 4.2 Vitolo U, Ferreri AJ, Montoto S (June 2008). "Follicular lymphomas". Crit. Rev. Oncol. Hematol. 66 (3): 248–61. doi:10.1016/j.critrevonc.2008.01.014. PMID 18359244.
- ↑ Bacon CM, Du MQ, Dogan A (April 2007). "Mucosa-associated lymphoid tissue (MALT) lymphoma: a practical guide for pathologists". J. Clin. Pathol. 60 (4): 361–72. doi:10.1136/jcp.2005.031146. PMC 2001121. PMID 16950858. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001121/.
- ↑ Papadaki, L.; Wotherspoon, AC.; Isaacson, PG. (Nov 1992). "The lymphoepithelial lesion of gastric low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT): an ultrastructural study.". Histopathology 21 (5): 415-21. PMID 1452124.
- ↑ DB. 6 August 2010.