CD99

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CD99 is a commonly available immunostain with various uses. It stains a lot of different tumour and has been described by one soft tissue pathologist as slutty.

Positive

Membrane staining

Ewing sarcoma - diffuse (plasma membrane) staining.
Lymphoblastic lymphoma/leukemia.
Angiomatoid fibrous histiocytoma.
Desmoplastic small round cell tumour.

Others

Malignant melanoma (9 of 10 cases^[1]).
Atypical fibroxanthoma (19 of 26 cases^[1]).

Negative

Squamous cell carcinoma.^[1]
Undifferentiated small round cell sarcoma with t(4;19) (CIC-DUX sarcoma) - negative or weak positive.

See also

Immunohistochemistry.

References

↑ ^1.0 ^1.1 ^1.2 Monteagudo, C.; Calduch, L.; Navarro, S.; Joan-Figueroa, A.; Llombart-Bosch, A. (Jan 2002). "CD99 immunoreactivity in atypical fibroxanthoma: a common feature of diagnostic value.". Am J Clin Pathol 117 (1): 126-31. doi:10.1309/2EXB-70CW-3U6P-VQ6H. PMID 11789717.

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Immunohistochemistry