Degenerative disc disease

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Degenerative disc disease, abbreviated DDD, is a common ditzel, typically generated in the course of a discectomy operation.

Degenerative disc disease
Diagnosis in short

Degenerative disc disease. HPS stain.

LM benign fibrous tissue, nests of chondrocytes
LM DDx chondrocalcinosis, synovial cyst, malignancy (primary or metastasis)
Site vertebral disc - see spine

Symptoms back pain
Prevalence common
Radiology disc herniation
Prognosis benign
Treatment surgical (e.g. discectomy)

Vertebral disc and discectomy redirect here.

General

  • Herniated disc cause back pain.
  • May result in cauda equina syndrome.
  • Composed of fibrous cartilage.[1]

Microscopic

Features:

  • Benign fibrous tissue.
  • Nests of chondrocytes (as in immature cartilage).
  • +/-Synovium with or without proliferation.[2]
  • +/-Neovascularization of disc material.[2]

DDx:

Images

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CERVICAL DISC, DISCECTOMY:
- DISC WITH DEGENERATIVE CHANGES.
- NO EVIDENCE OF MALIGNANCY.
LUMBAR DISC, DECOMPRESSION:
- DEGENERATIVE DISC DISEASE.

See also

References

  1. URL: http://www.lab.anhb.uwa.edu.au/mb140/CorePages/Cartilage/Cartil.htm. Accessed on: 2 January 2010.
  2. 2.0 2.1 2.2 2.3 Pytel, P.; Wollmann, RL.; Fessler, RG.; Krausz, TN.; Montag, AG. (Feb 2006). "Degenerative spine disease : pathologic findings in 985 surgical specimens.". Am J Clin Pathol 125 (2): 193-202. doi:10.1309/89FV-RT04-EGBV-EUD9. PMID 16393686.
  3. Modic, MT.; Ross, JS. (Oct 2007). "Lumbar degenerative disk disease.". Radiology 245 (1): 43-61. doi:10.1148/radiol.2451051706. PMID 17885180.