Tissue loss
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Tissue loss is relatively common in small biopsies.
It is estimated that approximately 27% of cases have a mismatch between the number of pieces seen at gross and microscopy.[1] A tissue gain is seen in approximately 25% of cases and a tissue loss is seen in approximately 7% of cases.[1]
This article also discusses tissue gain.
Possible cause of tissue gain
- Tissue fragmentation.
- Pseudofragmentation - two piece of tissue appears to be two in the plane of section.
- Tissue floater.
Possible causes of tissue loss
- Tissue floated from the slide.
- Material submitted soluble in the processing medium, e.g. mucous.
Work-up
- Melt the tissue block to looking for the lost tissue.
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Tissue loss
The block (A1) was melted to look for the missing core tissue; however, no tissue was found. The missing tissue appears to have been lost during processing or it consisted of material that is soluble in the processing fluids and dissolved.
See also
References
- ↑ 1.0 1.1 Owens, SR.; Wiehagen, L.; Simmons, C.; Sikorova, A.; Stewart, W.; Kelly, S.; Nestler, R.; Yousem, SA. (Dec 2011). "Numerical fidelity of endoscopic biopsy fragments in the processing sequence of a university surgical pathology laboratory.". Arch Pathol Lab Med 135 (12): 1561-4. doi:10.5858/arpa.2011-0020-OA. PMID 22129184.