Lobular capillary hemangioma
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Lobular capillary hemangioma, also known as pygenic granuloma,[1] a benign head and neck lesion that can mimic malignancy.
General
- Sometimes pregnancy tumour.
- Seen in children, young adults, pregnant women.
Clinical:
- May grow quickly - clinically suspicious for a malignancy.
Notes:
- Name of entity is a misnomer:
- Not pyogenic, i.e. infectious.
- Not granulomatous.
- The WMSP advocates the name lobular capillary hemangioma.[2]
Gross
Features:[3]
- Erythematous.
- Hemorrhagic.
Usually location:[2]
- Lips.
- Tongue.
- Gingiva.
Microscopic
Features:[4]
- Polypoid or peduculated.
- Vascular, i.e. many blood vessels, with plump endothelium.
- Usu. thinned epithelium[5] or ulcerated.[2]
- Lobular arrangement of vascular (seen at low power).[6]
DDx:
Why it is not...
- Glomus tumour - cookie cutter arrangement of cells.
Image
Pyogenic granuloma. (WC)
www:
IHC
Features - positive for vascular markers:[2]
- CD34 +ve.
- CD31 +ve.
- Factor VIII +ve.
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TONGUE, LEFT LATERAL, BIOPSY: - LOBULAR CAPILLARY HEMANGIOMA (PYOGENIC GRANULOMA).
Micro
The sections shows a pendunculated vascular lesion with small capillaries arranged in a lobular fashion. The endothelial cells of the lesion show no atypia. The overlying acanthotic epidermis has hyperkeratosis and hypergranulosis, and is focally ulcerated and impetiginized. There is no significant keratocyte atypia. No melanocytic nests are seen. The dermis has a mild perivascular lymphoplasmacytic infiltrate. The lesion is excised in the plane of section.
See also
References
- ↑ Baglin, AC. (Aug 2011). "[Vascular tumors and pseudotumors. Pyogenic granuloma (lobular capillary hemangioma)].". Ann Pathol 31 (4): 266-70. doi:10.1016/j.annpat.2011.05.014. PMID 21839350.
- ↑ 2.0 2.1 2.2 2.3 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 12. ISBN 978-0781765275.
- ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 776. ISBN 0-7216-0187-1.
- ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 775. ISBN 0-7216-0187-1.
- ↑ URL: http://basicpathology-histopathology.blogspot.com/2009/10/head-and-neck-oral-cavity-reactive_3282.html. Accessed on: 2 February 2011.
- ↑ S. Sade. 8 September 2011.
- ↑ Levy, I.; Rolain, JM.; Lepidi, H.; Raoult, D.; Feinmesser, M.; Lapidoth, M.; Ben-Amitai, D. (Dec 2005). "Is pyogenic granuloma associated with Bartonella infection?". J Am Acad Dermatol 53 (6): 1065-6. doi:10.1016/j.jaad.2005.08.046. PMID 16310070.