Trisomy 21

From Libre Pathology
Revision as of 20:56, 29 May 2011 by Michael (talk | contribs) (tweak a bit more)
Jump to navigation Jump to search

Trisomy 21, also known as Down syndrome, is a common genetic abnormality.

Characteristics

Mnemonic CHILD HAS PROBLEM:[1]

  • Congenital heart disease / Cataracts.
  • Hypotonia / Hypothyroidism.
  • Incurved 5th digit (clinodactyly)[2] / Increased gap between 1st and 2nd toe.
  • Leukemia risk x2 / Lung problem.
  • Duodenal atresia / Delayed development.
  • Hirschsprung disease / Hearing loss.
  • Alzheimer disease / Alantoaxial instability.
  • Squint / Short neck.
  • Protruding tongue/ Palmar crease.
  • Round face / Rolling eye (nystagmus).
  • Occiput flat / Oblique eye fissure.
  • Brushfield spot / Brachycephaly.
  • Low nasal bridge / Language problems.
  • Epicanthic fold / Ears folded.
  • Mental retardation / Myoclonus.

See also

References

External links