Clear cell carcinoma of the urinary bladder

Clear cell carcinoma of the urinary bladder is a rare subtype of primary adenocarcinoma of the urinary bladder.

Clear cell carcinoma of the urinary bladder
Diagnosis in short
Synonyms	mesonephroid adenocarcinoma, mesonephroid carcinoma
Subtypes	subtype of primary adenocarcinoma of the urinary bladder
LM DDx	nephrogenic adenoma, other subtypes of adenocarcinoma of the urinary bladder, urachal carcinoma
Site	urinary bladder
Clinical history	typically female
Prevalence	very rare - case reports
Prognosis	poor (?)

It is also known as mesonephroid adenocarcinoma of the urinary bladder, adenocarcinoma of bladder, mesonephroid type and mesonephroid carcinoma.

General

• Extremely rare - 7 cases reported as of 2013.
• Female predominance (F:M ~ 2:1).

Microscopic

Features:

• Moderately differentiated clear cell adenocarcinoma.

DDx:

• Nephrogenic adenoma.
• Other subtypes of adenocarcinoma of the urinary bladder.
• Urachal carcinoma.

IHC

Features:

• CK7 +ve.
• CD10 +ve.
• CA-125 +ve.
• GATA3 +ve.

Others:

• ER -ve.
• PR -ve.
• CDX2 -ve.
• AFP -ve.
• PSA -ve.

See also

• Urinary bladder.
• Clear cell adenocarcinoma.