Bizarre parosteal osteochondromatous proliferation
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| Bizarre parosteal osteochondromatous proliferation | |
|---|---|
| Diagnosis in short | |
|
| |
| Synonyms | Nora lesion |
| Site | Hands, feet |
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| |
General
A distinctive osteochondromatous proliferation of hands and feet.
Population
- Young adults
- 20s-30s
Location
Hands and feet
Radiology
Marginated wide based bony growth projecting into the soft tissues[1]
Gross
- Nodule covered with glistening cartilage
Microscopic
Disorganized cellular cartilage with a blue tint and patchy ossification matures into disorganized bone. A proliferation of fibroblasts surrounds the lesion and occupies intertrabecular spaces.
Images
![[1]](http://www.webpathology.com/images/noimage.gif){kind=link}
![[2]](http://webpathology.com/images/noimage.gif){kind=link}
![[4]](http://pathologyoutlines.com/wick/bizarre%20parosteal%20osteochondromatous%20proliferation%20(bpop-%20no.jpg){kind=link}
DDX
- Periosteal chondrosarcoma
- Periosteal chondroma
- Low grade parosteal osteosarcoma
- Osteochondroma
Diangostic categories
- Cartilaginous neoplasms
- Osteocartilaginous neoplasms
Molecular
t(1:17)(q32;q21)[2]
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BIZARRE PAROSTEAL OSTEOCHONDROMATOUS PROLIFERATION (NORA LESION).
Prognosis
- Benign
- Locally aggressive
See also
- Pathology Outlines[5]
References
- ↑ http://radiopaedia.org/articles/bizarre-parosteal-osteochondromatous-proliferation
- ↑ Kuruvilla, S.; Marco, R.; Raymond, AK.; Al-Ibraheemi, A.; Tatevian, N. (2011). "BizarreParosteal Osteochondromatous Proliferation (Nora's lesion) with translocation t(1;17)(q32;q21): a case report and role of cytogenetic studies on diagnosis.". Ann Clin Lab Sci 41 (3): 285-7. PMID 22075515.