Cystic medial degeneration

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Cystic medial degeneration (abbreviated CMD), also cystic medial necrosis,[1] is vascular pathology of the large blood vessels. It is suggestive of an underlying connective tissue disorder.

General

  • Nonspecific finding - may be seen in a number of conditions.
  • "Medial" refers to tunica media the middle (muscle) layer of an artery.

Note about cystic medial necrosis:

  • Often not cystic and not necrotic.

Microscopic

Features:[2][3]

  • Basophilic ground substance in the media (seen on Movat's stain).
  • Disruption of the elastic lamina (seen on elastic trichrome stain).
  • +/-Focal necrosis.

Images

  • Cystic medial degeneration - low mag. (WC/Nephron)

  • Cystic medial degeneration - high mag. (WC/Nephron)

  • Cystic medial degeneration - movat - low mag. (WC/Nephron)

  • Cystic medial degeneration - movat - intermed. mag. (WC/Nephron)

www:

Stains

See also

References

  1. ↑ URL: http://emedicine.medscape.com/article/756835-overview. Accessed on: 12 August 2010.
  2. ↑ URL: http://emedicine.medscape.com/article/756835-overview. Accessed on: 12 August 2010.
  3. ↑ Ha HI, Seo JB, Lee SH, et al. (2007). "Imaging of Marfan syndrome: multisystemic manifestations". Radiographics 27 (4): 989–1004. doi:10.1148/rg.274065171. PMID 17620463. http://radiographics.rsna.org/content/27/4/989.full.
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