Littoral cell angioma

Littoral cell angioma
Diagnosis in short
Littoral cell angioma. H&E stain.
LM	anastoming, small vascular channels, cystic spaces - may have papillary projections
LM DDx	hemangioendothelioma, angiosarcoma, hemangiopericytoma, splenic hamartoma
IHC	lining cells: CD68 +ve, CD31 +ve, CD34 -ve, CD8 -ve
Site	spleen
Clinical history	weight loss
Signs	pyrexia (fever), splenomegaly
Prevalence	rare
Radiology	solitary hypodense lesion
Prognosis	benign

Littoral cell angioma, abbreviated LCA, is an uncommon benign vascular lesion of the spleen.

Angioma, in general, is dealt with in vascular malformations.

General

Features:

• Rare.
• Benign.

Clinical:

• Pyrexia (fever), splenomegaly, weight loss, solitary hypodense lesion on imaging.

Note:

• Littoral cells = line vascular channels of the red pulp.
  • Littoral = related to shore.

Microscopic

Features:

• Anastoming, small vascular channels.
• Cystic spaces.
  • May have papillary projections.

DDx:

• Vascular lesions:
  • Hemangioendothelioma.
  • Angiosarcoma.
  • Hemangiopericytoma.
  • Splenic hamartoma.
  • Splenic hemangioma.

Images

• 

  LCA - very low mag. (WC)

• 

  LCA - low mag. (WC)

• 

  LCA - intermed. mag. (WC)

• 

  LCA - high mag. (WC)

• 

  LCA - very high mag. (WC)

www:

• LCA - low mag. (webpathology.com).
• LCA - high mag. (webpathology.com).

IHC

Features:

• CD68 +ve.
• CD31 +ve

Others:

• CD34 -ve (normally in red pulp).
• CD8 -ve (normally in red pulp).
• Factor VIII +ve.

See also

• Spleen.