Bile duct adenoma
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Bile duct adenoma is a benign liver lesion characterized composed of bile duct epithelium.
It is also known as a benign bile duct proliferation.[1]
General
- Benign.
- Important as it can be misdiagnosed as cancer.
Microscopic
Features:
- Disordered bile ducts within in a fibrotic stroma.
- No (yellow) bile within, as these lesions do not have a connection to the biliary tree.
- +/-Lymphocytic cuff.
Negatives:
- No mitotic activity.
- No necrosis.
DDx:
- Cholangiocarcinoma.
- Pancreatic ductal adenocarcinoma.[2]
- Metastatic adenocarcinoma.
- Bile duct hamartoma (von Meyenburg complex).
Images
IHC
- CK7 +ve.
- HepPar-1 -ve.
- Ki-67 low.
Others:[2]
- p53 -ve.
- mCEA -ve.
See also
References
- ↑ Johannesen, EJ.; Wu, Z.; Holly, JS. (2014). "Bile duct adenoma with oncocytic features.". Case Rep Pathol 2014: 282010. doi:10.1155/2014/282010. PMID 24592348.
- ↑ 2.0 2.1 Hornick, JL.; Lauwers, GY.; Odze, RD. (Mar 2005). "Immunohistochemistry can help distinguish metastatic pancreatic adenocarcinomas from bile duct adenomas and hamartomas of the liver.". Am J Surg Pathol 29 (3): 381-9. PMID 15725808.