Renal mucinous tubular and spindle cell carcinoma

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Renal mucinous tubular and spindle cell carcinoma, abbreviated RMTSCC, is a rare malignant epithelial neoplasm of the kidney.

It is also known as renal mucinous tubular spindle cell carcinoma and mucinous tubular and spindle cell carcinoma of the kidney.[1]

General

  • Rare.[2]
  • Accepted by WHO in 2004 as a separate entity.[3]
  • Relatively good prognosis.

Gross

Features:[4]

  • Solid.
  • Greyish-yellow or tan-yellow.
  • Well-circumscribed.

Microscopic

Features:[5]

  • Mucin (foamy macrophages) - may be scant.
  • Spindle cells - key feature.
  • Small tubules - lined by cuboidal epithelium.[4]

DDx:

Images

www:

Stains

IHC

Features:[9]

  • CD10 -ve.
  • AE1/AE3 +ve.
  • AMACR +ve.
  • CK7 +ve.

Note:

See also

References

  1. ↑ Brandal, P.; Lie, AK.; Bassarova, A.; Svindland, A.; Risberg, B.; Danielsen, H.; Heim, S. (Feb 2006). "Genomic aberrations in mucinous tubular and spindle cell renal cell carcinomas.". Mod Pathol 19 (2): 186-94. doi:10.1038/modpathol.3800499. PMID 16258504.
  2. ↑ Srigley, JR.; Delahunt, B. (Jun 2009). "Uncommon and recently described renal carcinomas.". Mod Pathol 22 Suppl 2: S2-S23. doi:10.1038/modpathol.2009.70. PMID 19494850.
  3. ↑ Geramizadeh B, Salehipour M, Moradi A (2009). "Mucinous tubular and spindle cell carcinoma of kidney: a rare case report and review of the literature". Indian J Pathol Microbiol 52 (4): 514–6. doi:10.4103/0377-4929.56144. PMID 19805959.
  4. ↑ 4.0 4.1 4.2 Wu, XR.; Chen, YH.; Sha, JJ.; Zhao, L.; Huang, JW.; Bo, JJ.; Liu, DM.; Huang, YR. (Dec 2013). "Renal mucinous tubular and spindle cell carcinoma: a report of 8 cases and review of the literature.". Diagn Pathol 8 (1): 206. doi:10.1186/1746-1596-8-206. PMID 24330589.
  5. ↑ Trabelsi A, Stita W, Yacoubi MT, Rammeh S, Hmissa S, Korbi S (December 2008). "Renal mucinous tubular and spindle cell carcinoma". Can Urol Assoc J 2 (6): 635–6. PMC 2593603. PMID 19066686. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593603/.
  6. ↑ Dhillon J, Amin MB, Selbs E, Turi GK, Paner GP, Reuter VE (January 2009). "Mucinous tubular and spindle cell carcinoma of the kidney with sarcomatoid change". Am. J. Surg. Pathol. 33 (1): 44–9. doi:10.1097/PAS.0b013e3181829ed5. PMID 18941398.
  7. ↑ URL: http://www.cttr.org/cms/?p=1406. Accessed on: 28 February 2014.
  8. ↑ Hussain, M.; Ud Din, N.; Azam, M.; Loya, A.. "Mucinous tubular and spindle cell carcinoma of kidney: a clinicopathologic study of six cases.". Indian J Pathol Microbiol 55 (4): 439-42. doi:10.4103/0377-4929.107776. PMID 23455776.
  9. ↑ Ferlicot S, Allory Y, Compérat E, et al. (December 2005). "Mucinous tubular and spindle cell carcinoma: a report of 15 cases and a review of the literature". Virchows Arch. 447 (6): 978–83. doi:10.1007/s00428-005-0036-x. PMID 16231179.
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