Secretory carcinoma of the salivary gland
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Mammary analogue secretory carcinoma, abbreviated MASC, is a newly described malignant salivary gland tumour.[1]
General
- Described in pediatric patient.[2]
Microscopic
Features:
- Large cells with abundant cytoplasm.
- Small nuclei.
- +/-Lymphocytic infiltrate.
DDx:
- Acinic cell carcinoma - very closely mimics.
- Mucoepidermoid carcinoma.
Images
IHC
- S-100 +ve.[1]
Molecular
- t(12;15)(p13;q25).
- Fusion of the genes ETV6 and NTRK3.[1]
Note:
- The translocation seen in congenital-infantile fibrosarcoma.
See also
References
- ↑ 1.0 1.1 1.2 1.3 Lei, Y.; Chiosea, SI. (Jun 2012). "Re-evaluating historic cohort of salivary acinic cell carcinoma with new diagnostic tools.". Head Neck Pathol 6 (2): 166-70. doi:10.1007/s12105-011-0312-9. PMID 22127547.
- ↑ Rastatter, JC.; Jatana, KR.; Jennings, LJ.; Melin-Aldana, H. (Mar 2012). "Mammary analogue secretory carcinoma of the parotid gland in a pediatric patient.". Otolaryngol Head Neck Surg 146 (3): 514-5. doi:10.1177/0194599811419044. PMID 21873597.