Uterine cervix with atrophic changes

Uterine cervix with atrophic changes is relatively common and is important to recognize as it can mimic HSIL.

It is also known as atrophy of the uterine cervix, cervical atrophy, atrophy of the cervix and cervix with atrophic changes.

General

• Common.
• Post-menupausal.
• Important to recognize and differentiate from HSIL.

Microscopic

Features:

• Cells smaller.
• Cytoplasm grey/blue.
• No "dancing"/"sparkling" chromatin.
• No mitoses.

DDx:

• HSIL.

Images

www:

• Atrophic cervix (nih.techriver.net).
• Atrophic cervix (flickriver.com/euthman).
• Atrophic changes in the vagina (eurocytology.eu).

IHC

• p16 -ve.
• Ki-67 rare basal cells.

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UTERINE CERVIX, BIOPSY:
- SQUAMOUS MUCOSA WITH ATROPHIC CHANGES.
- BENIGN ENDOCERVICAL EPITHELIUM.
- NEGATIVE FOR DYSPLASIA.

COMMENT:
A p16 immunostain is negative. A Ki-67 immunostain marks rare basal cells.

See also

• Uterine cervix.