Hemolytic uremic syndrome

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Hemolytic uremic syndrome, abbreviated HUS, is the triad of:[1]

  • Microangiopathic hemolytic anemia.
  • Thrombocytopenia.
  • Acute renal failure.

Etiology

  • Verotoxins (from E. coli O157:H7) --> endothelial injury.[2]

Relation to thrombotic thrombocytopenic purpura (TTP)

  • TTP is the main (clinical) DDx of HUS.
    • It is classically characterized by: microangiopathic hemolytic anemia, thrombocytopenia, fever, mild renal failure, and prominent neurologic symptoms.
  • Both are classified as thrombotic microangiopathies.[3]

Etiology

  • Rare hamburger.
  • E. coli serotype O157:H7.

See also

References

  1. ↑ URL: http://emedicine.medscape.com/article/779218-overview. Accessed on: 8 September 2010.
  2. ↑ Petruzziello TN, Mawji IA, Khan M, Marsden PA (February 2009). "Verotoxin biology: molecular events in vascular endothelial injury". Kidney Int. Suppl. (112): S17–9. doi:10.1038/ki.2008.612. PMID 19180125.
  3. ↑ URL: http://emedicine.medscape.com/article/779218-overview. Accessed on: 8 September 2010.
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