Mast cell

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The mast cell is an uncommonly cell that occasionally causes problems.

Microscopic

Features:

  • Ovoid/round cell with moderate amount of gray granular cytoplasm.
  • Nuclear ovoid/round.
    • No obvious nucleolus.
  • May be more abundant around blood vessels.

Notes:

  • Lymphocyte vs. mast cell:
    • Lymphocytes = round; mast cells = ovoid.

Images:

Diseases

Conditions associated with the presence of mast cells

Stains

IHC

  • CD117 +ve.

References

  1. Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 370-2. ISBN 978-1416054542.
  2. Carr, NJ.; Warren, AY. (Jan 1993). "Mast cell numbers in melanocytic naevi and cutaneous neurofibromas.". J Clin Pathol 46 (1): 86-7. PMID 8432898.
  3. URL: http://www.nature.com/jid/journal/v53/n1/full/jid1969105a.html. Accessed on: 20 December 2011.