Oncocytoma of the salivary gland
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Oncocytoma of the salivary gland is a rare benign tumour of the salivary glands.
General
- No risk of malignant transformation.
- Rare ~20 reported in literature.[1]
- Thought to be ~1% of all salivary gland tumours.
- Typical age: 60s-80s.
- Associated with radiation exposure.
- Major salivary glands - usually parotid gland.[2]
Gross
- Golden brown appearance.
Image
Salivary gland oncocytoma (WC/euthman)
Microscopic
Features:
- Like oncocytomas elsewhere.
- Eosinophilic cytoplasm (on H&E stain).
- Due to increased number of mitochrondria.
- Fine capillaries.
- Eosinophilic cytoplasm (on H&E stain).
- Architecture: solid sheets, trabeculae or duct-like structure.[2]
Notes:
- May have clear cell change.
- Multiple small incidental lesions = oncocytosis - not oncocytoma.
DDx:
Images
www:
Parotid gland oncocytoma - intermed. mag. (WC/Nephron)
Parotid gland oncocytoma - high mag. (WC/Nephron)
Parotid gland oncocytoma - very high mag. (WC/Nephron)
IHC
- p63 +ve[3] focally in nucleus.
See also
References
- ↑ Uzunkulaoğlu H, Yazici H, Can IH, Doğan S, Uzunkulaoğlu T (May 2012). "Bilateral oncocytoma in the parotid gland". J Craniofac Surg 23 (3): e246–7. doi:10.1097/SCS.0b013e31824dfccd. PMID 22627459.
- ↑ 2.0 2.1 Zhou, CX.; Gao, Y. (Dec 2009). "Oncocytoma of the salivary glands: a clinicopathologic and immunohistochemical study.". Oral Oncol 45 (12): e232-8. doi:10.1016/j.oraloncology.2009.08.004. PMID 19796983.
- ↑ 3.0 3.1 McHugh, JB.; Hoschar, AP.; Dvorakova, M.; Parwani, AV.; Barnes, EL.; Seethala, RR. (Dec 2007). "p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma.". Head Neck Pathol 1 (2): 123-31. doi:10.1007/s12105-007-0031-4. PMC 2807526. PMID 20614263. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807526/.