Zollinger-Ellison syndrome

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Zollinger-Ellison syndrome, abbreviated ZES, is the triad of pancreatic gastrinoma, peptic ulcers of the small bowel and gastric hypersecretion.[1]

General

Clinical:

  • Abdominal pain.
  • Diarrhea.

Laboratory:

  • Serum gastrin often elevated - though not usually not very high.[2]

Microscopic

See: Pancreatic neuroendocrine tumour.

See also

References

  1. Zollinger RM, Ellison EH (1955). "Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas". Ann. Surg. 142 (4): 709–23; discussion, 724–8. doi:10.1097/00000658-195510000-00015. PMC 1465210. PMID 13259432. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1465210/.
  2. Berna, MJ.; Hoffmann, KM.; Serrano, J.; Gibril, F.; Jensen, RT. (Nov 2006). "Serum gastrin in Zollinger-Ellison syndrome: I. Prospective study of fasting serum gastrin in 309 patients from the National Institutes of Health and comparison with 2229 cases from the literature.". Medicine (Baltimore) 85 (6): 295-330. doi:10.1097/01.md.0000236956.74128.76. PMID 17108778.