Medullary breast carcinoma

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Medullary breast carcinoma is an uncommon form of invasive breast carcinoma.

It is also known as medullary carcinoma of the breast.

General

  • Uncommon breast cancer subtype.
  • Some pathologists very rarely make the diagnosis.[citation needed]

Epidemiology:

  • Thought to have a better prognosis that no special type (NST).
  • May be associated with a BRCA1 mutation.

Gross

  • Well-circumscribed border.[1]

Aside - malignant well-circumscribed breast masses - radiologic DDx:[1]

Microscopic

Features:

  1. Lesion has well-circumscribed border.
  2. Syncytial growth pattern = clumps of cells with poorly defined cell borders.
  3. Lymphocytic infiltrate.
  4. High nuclear grade (as per Nottingham grading system).
  5. No tubule formation.

IHC

Features - typical:[2]

  • ER -ve.
  • PR -ve.
  • HER2 -ve.

See also

References

  1. 1.0 1.1 Yoo, JL.; Woo, OH.; Kim, YK.; Cho, KR.; Yong, HS.; Seo, BK.; Kim, A.; Kang, EY. (Oct 2010). "Can MR Imaging contribute in characterizing well-circumscribed breast carcinomas?". Radiographics 30 (6): 1689-702. doi:10.1148/rg.306105511. PMID 21071383.
  2. Matkovic, B.; Juretic, A.; Separovic, V.; Novosel, I.; Separovic, R.; Gamulin, M.; Kruslin, B.. "Immunohistochemical analysis of ER, PR, HER-2, CK 5/6, p63 and EGFR antigen expression in medullary breast cancer.". Tumori 94 (6): 838-44. PMID 19267102.