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Difference between revisions of "Prostate gland"
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→Cancer: +mimics
(→Cancer: +mimics) |
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*AMACR +ve, p63 -ve, HMWCK (34betaE12) -ve . | *AMACR +ve, p63 -ve, HMWCK (34betaE12) -ve . | ||
*Usually positive: PSA, PSAP. | *Usually positive: PSA, PSAP. | ||
===Mimics of prostate adenocarcinoma=== | |||
Mimics of prostate adenocarcinoma:<ref>TPOSP. PP.100-3.</ref> | |||
{| class="wikitable" | |||
| '''Entity''' | |||
| '''Key feature''' | |||
| '''Detailed microscopic''' | |||
| '''Other''' | |||
| '''Image''' | |||
|- | |||
| Adenosis | |||
| gradual transition between normal & small gland (NOT two populations) | |||
| many small glands, lack nuclear size variation, basal layer present | |||
| nucleoli may be present; may need to do p63 or 34betaE12 to find basal layer | |||
| '''Image''' | |||
|- | |||
| Sclerosing adenosis | |||
| gradual transition between normal & small gland (NOT two populations), fibrosis | |||
| many small glands, lack nuclear size variation, basal layer present | |||
| analogous to sclerosing adenosis of breast (???) | |||
| '''Image''' | |||
|- | |||
| Atropy | |||
| scant cytoplasm | |||
| nuclear hyperchromasia | |||
| may appear right beside non-atrophic tissue | |||
| '''Image''' | |||
|- | |||
| Basal cell hyperplasia | |||
| two distinct cell populations (in epithelial component) | |||
| abundant epithelium, nucleoli, no nuclear size var. | |||
| vaguely similar to epithelial hyperplasia of usual type (EHUT) in breast | |||
| '''Image''' | |||
|- | |||
| Bulbourethral gland | |||
| no nuclear atypia | |||
| clear cytoplasm | |||
| apex of prostate | |||
| '''Image''' | |||
|- | |||
| Seminal vesicles | |||
| lipofuscin (yellow granular material in cytoplasm) | |||
| fern-like arrangement of epithelium, nucleoli, surrounded by muscle | |||
| involvement by cancer changes staging | |||
| '''Image''' | |||
|- | |||
| Radiation exposure | |||
| marked nuclear size variation | |||
| lack nucleoli ??? | |||
| history of Rx; uniform nuc. size with Hx of Rx should raise susp. of cancer | |||
| '''Image''' | |||
|} | |||
===Grading=== | ===Grading=== | ||