Difference between revisions of "Multicystic dysplastic kidney"
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==Microscopic== | ==Microscopic== | ||
Features:<ref name=Ref_Klatt237>{{Ref Klatt|237}}</ref><ref name=pmid33252759/> | Features:<ref name=Ref_Klatt237>{{Ref Klatt|237}}</ref><ref name=pmid33252759/> | ||
*Cystic spaces of variable size. | *Cystic spaces of variable size, lined by cuboidal cells. | ||
*Fibrous stroma. | *Fibrous stroma. | ||
*Islands of cartilage. | *Islands of cartilage. | ||
Revision as of 17:07, 4 February 2025
Multicystic dysplastic kidney, abbreviated MCDK, is a cystic disease of the kidney. It is also known as multicystic renal dysplasia (abbreviated as MRD).[1]
General
- Most common cause of abdominal mass in newborns.[2]
- May be unilateral or involve only part of a kidney.[3]
Etiology:
- Embryological malformation.[4]
- Normal development: renal collecting system forms when ureteric bud (which grows from cloaca) meets the renal blastema (the kidney parenchyma precursor).
- In MCDK ureteric bud and renal blastema fail to meet.
Gross
- Kidney has multiple large cysts or differing sizes.
DDx:
- ARPKD - has less variability of cyst size.
Images:
Microscopic
- Cystic spaces of variable size, lined by cuboidal cells.
- Fibrous stroma.
- Islands of cartilage.
Image:
Note:
- Cysts do not communicate with one another.[4]
See also
References
- ↑ Multicystic Dysplastic Kidney. National Institutes of Health (United States). URL: https://www.niddk.nih.gov/health-information/kidney-disease/children/multicystic-dysplastic-kidney]. Accessed on: 2025-Feb-04.
- ↑ URL: http://emedicine.medscape.com/article/982560-overview. Accessed on: 4 January 2012.
- ↑ Jump up to: 3.0 3.1 Klatt, Edward C. (2006). Robbins and Cotran Atlas of Pathology (1st ed.). Saunders. pp. 237. ISBN 978-1416002741.
- ↑ Jump up to: 4.0 4.1 4.2 PubMed 33252759