Difference between revisions of "Glycoprotein non-metastatic B"
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It is typically positive in TSC1/TSC2/MTOR mutated renal cell carcinomas.<ref name=pmid37661807>{{cite journal |authors=Li H, Argani P, Halper-Stromberg E, Lotan TL, Merino MJ, Reuter VE, Matoso A |title=Positive GPNMB Immunostaining Differentiates Renal Cell Carcinoma With Fibromyomatous Stroma Associated With TSC1/2/MTOR Alterations From Others |journal=Am J Surg Pathol |volume=47 |issue=11 |pages=1267–1273 |date=November 2023 |pmid=37661807 |doi=10.1097/PAS.0000000000002117 |url=}}</ref> | It is typically positive in TSC1/TSC2/MTOR mutated renal cell carcinomas.<ref name=pmid37661807>{{cite journal |authors=Li H, Argani P, Halper-Stromberg E, Lotan TL, Merino MJ, Reuter VE, Matoso A |title=Positive GPNMB Immunostaining Differentiates Renal Cell Carcinoma With Fibromyomatous Stroma Associated With TSC1/2/MTOR Alterations From Others |journal=Am J Surg Pathol |volume=47 |issue=11 |pages=1267–1273 |date=November 2023 |pmid=37661807 |doi=10.1097/PAS.0000000000002117 |url=}}</ref> | ||
==Positive== | ==Positive== | ||
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*[[PEComa]]. | *[[PEComa]]. | ||
*[[Renal cell carcinoma with fibromyomatous stroma]]. | *[[Renal cell carcinoma with fibromyomatous stroma]]. | ||
==Negative | |||
*[[Clear cell renal cell carcinoma]]. | |||
*[[Papillary renal cell carcinoma]]. | |||
*[[Chromophobe renal cell carcinoma]]. | |||
*[[Clear cell papillary renal cell tumour]]. | |||
==References== | ==References== | ||
Revision as of 13:29, 26 March 2024
Glycoprotein non-metastatic B, abbreviated GPNMB, is an immunostain.
It is typically positive in TSC1/TSC2/MTOR mutated renal cell carcinomas.[1]
Positive
- Angiomyolipoma.
- TFE3-rearranged renal cell carcinoma.
- TFEB-rearranged renal cell carcinoma.
- Low-grade oncocytic tumour (LOT).
- PEComa.
- Renal cell carcinoma with fibromyomatous stroma.
==Negative
- Clear cell renal cell carcinoma.
- Papillary renal cell carcinoma.
- Chromophobe renal cell carcinoma.
- Clear cell papillary renal cell tumour.
References
- ↑ Li H, Argani P, Halper-Stromberg E, Lotan TL, Merino MJ, Reuter VE, Matoso A (November 2023). "Positive GPNMB Immunostaining Differentiates Renal Cell Carcinoma With Fibromyomatous Stroma Associated With TSC1/2/MTOR Alterations From Others". Am J Surg Pathol 47 (11): 1267–1273. doi:10.1097/PAS.0000000000002117. PMID 37661807.