Difference between revisions of "Biphasic hyalinizing psammomatous renal cell carcinoma"
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==Microscopic== | ==Microscopic== | ||
Features: | Features:<ref name=pmid32217839/> | ||
*Biphasic cytomorphology: | *Biphasic cytomorphology: | ||
*#Small cells. | *#Small cells. | ||
| Line 10: | Line 10: | ||
DDx: | DDx: | ||
*[[TFEB renal cell carcinoma]]. | *[[TFEB renal cell carcinoma]]. | ||
==IHC== | |||
Features:<ref name=pmid32217839/> | |||
*HNF-1beta +ve | |||
*PAX8 +ve | |||
*CK7 +ve | |||
*EMA +ve. | |||
*AMACR +ve. | |||
*WT1 -ve | |||
*Melan A -ve. | |||
*HMB-45 -ve. | |||
*GATA3 -ve. | |||
*Chromogranin A -ve. | |||
*Synaptophysin -ve. | |||
*FH normal. | |||
*SDHB normal. | |||
==References== | ==References== | ||
Revision as of 02:42, 13 October 2021
Biphasic hyalinizing psammomatous renal cell carcinoma, abbreviated BHP RCC, is a rare type of renal cell carcinoma with mutations in neurofibromin 2.[1]
Microscopic
Features:[1]
- Biphasic cytomorphology:
- Small cells.
- Large cells.
- Psammoma bodies.
DDx:
IHC
Features:[1]
- HNF-1beta +ve
- PAX8 +ve
- CK7 +ve
- EMA +ve.
- AMACR +ve.
- WT1 -ve
- Melan A -ve.
- HMB-45 -ve.
- GATA3 -ve.
- Chromogranin A -ve.
- Synaptophysin -ve.
- FH normal.
- SDHB normal.
References
- ↑ 1.0 1.1 1.2 "Biphasic Hyalinizing Psammomatous Renal Cell Carcinoma (BHP RCC): A Distinctive Neoplasm Associated With Somatic NF2 Mutations". Am J Surg Pathol 44 (7): 901–916. July 2020. doi:10.1097/PAS.0000000000001467. PMC 7350624. PMID 32217839. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350624/.