Difference between revisions of "Paired box gene 8"
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[[Image:Lymphoma - lung - PAX8 -- intermed mag.jpg|thumb|right|300px|Negative PAX8 staining in a lymphoma.]] | [[Image:Lymphoma - lung - PAX8 -- intermed mag.jpg|thumb|right|300px|Negative PAX8 staining in a lymphoma.]] | ||
*[[Urothelial carcinoma]] - can be positive (3 positive/18 bladder tumours<ref name=pmid21552115/>). | *[[Urothelial carcinoma]] - can be positive (3 positive/18 bladder tumours<ref name=pmid21552115/>). | ||
*[[Lymphoma]] (beware false positive staining due to polyclonal PAX8 antibodies cross-reacting with PAX5)<ref name=pmid22037256>{{cite journal |vauthors=Moretti L, Medeiros LJ, Kunkalla K, Williams MD, Singh RR, Vega F |title=N-terminal PAX8 polyclonal antibody shows cross-reactivity with N-terminal region of PAX5 and is responsible for reports of PAX8 positivity in malignant lymphomas |journal=Mod. Pathol. |volume=25 |issue=2 |pages=231–6 |date=February 2012 |pmid=22037256 |doi=10.1038/modpathol.2011.162 |url=}}</ref> | *[[Lymphoma]] (beware false positive staining due to polyclonal PAX8 antibodies cross-reacting with [[PAX5]])<ref name=pmid22037256>{{cite journal |vauthors=Moretti L, Medeiros LJ, Kunkalla K, Williams MD, Singh RR, Vega F |title=N-terminal PAX8 polyclonal antibody shows cross-reactivity with N-terminal region of PAX5 and is responsible for reports of PAX8 positivity in malignant lymphomas |journal=Mod. Pathol. |volume=25 |issue=2 |pages=231–6 |date=February 2012 |pmid=22037256 |doi=10.1038/modpathol.2011.162 |url=}}</ref> | ||
*[[Malignant melanoma]].<ref name=pmid21285870>{{Cite journal | last1 = Tacha | first1 = D. | last2 = Zhou | first2 = D. | last3 = Cheng | first3 = L. | title = Expression of PAX8 in normal and neoplastic tissues: a comprehensive immunohistochemical study. | journal = Appl Immunohistochem Mol Morphol | volume = 19 | issue = 4 | pages = 293-9 | month = Jul | year = 2011 | doi = 10.1097/PAI.0b013e3182025f66 | PMID = 21285870 }}</ref> | *[[Malignant melanoma]].<ref name=pmid21285870>{{Cite journal | last1 = Tacha | first1 = D. | last2 = Zhou | first2 = D. | last3 = Cheng | first3 = L. | title = Expression of PAX8 in normal and neoplastic tissues: a comprehensive immunohistochemical study. | journal = Appl Immunohistochem Mol Morphol | volume = 19 | issue = 4 | pages = 293-9 | month = Jul | year = 2011 | doi = 10.1097/PAI.0b013e3182025f66 | PMID = 21285870 }}</ref> | ||
Revision as of 12:09, 14 November 2020
| Paired box gene 8 | |
|---|---|
| Immunostain in short | |
 PAX8 staining in a poorly differentiated carcinoma. | |
| Abbreviation | PAX8 |
| Use | RCC versus other, gynecologic tract malignancy versus other |
| Subspeciality | gynecologic pathology, genitourinary pathology |
| Normal staining pattern | nuclear stain |
| Positive | renal cell carcinomas, renal oncocytoma, thyroid tumours, serous carcinoma, endometrial carcinomas |
Paired box gene 8, commonly known by the abbreviation PAX8, is a commonly used immunostain in gynecologic pathology and genitourinary pathology.
Tumours with positive staining
- Thyroid tumours ~ 90%.[1]
- Renal cell carcinomas ~ 90%.[1]
- Renal oncocytomas ~ 80%.[1]
- High-grade ovarian serous carcinomas ~ 99%.[1]
- Nonserous epithelial ovarian neoplasms ~ 70%.[1]
- Endometrial carcinomas ~ 98%.[1]
- Pancreatic neuroendocrine tumour ~ 74%.[2]
- Can help differentiate from lung NETs.
- Epithelial component of thymic tumors 77-100% depending on sub-type[1][3]
May be positive
- Peritoneal malignant mesothelioma (5 +ve of 27[4]).
Negative staining
- Urothelial carcinoma - can be positive (3 positive/18 bladder tumours[1]).
- Lymphoma (beware false positive staining due to polyclonal PAX8 antibodies cross-reacting with PAX5)[5]
- Malignant melanoma.[6]
See also
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Laury, AR.; Perets, R.; Piao, H.; Krane, JF.; Barletta, JA.; French, C.; Chirieac, LR.; Lis, R. et al. (Jun 2011). "A comprehensive analysis of PAX8 expression in human epithelial tumors.". Am J Surg Pathol 35 (6): 816-26. doi:10.1097/PAS.0b013e318216c112. PMID 21552115.
- ↑ Sangoi, AR.; Ohgami, RS.; Pai, RK.; Beck, AH.; McKenney, JK.; Pai, RK. (Mar 2011). "PAX8 expression reliably distinguishes pancreatic well-differentiated neuroendocrine tumors from ileal and pulmonary well-differentiated neuroendocrine tumors and pancreatic acinar cell carcinoma.". Mod Pathol 24 (3): 412-24. doi:10.1038/modpathol.2010.176. PMID 20890270.
- ↑ "Pax8 expression in thymic epithelial neoplasms: an immunohistochemical analysis". Am. J. Surg. Pathol. 35 (9): 1305–10. September 2011. doi:10.1097/PAS.0b013e3182260735. PMID 21836478.
- ↑ "PAX8 Expression in a Subset of Malignant Peritoneal Mesotheliomas and Benign Mesothelium has Diagnostic Implications in the Differential Diagnosis of Ovarian Serous Carcinoma". Am. J. Surg. Pathol. 41 (12): 1675–1682. December 2017. doi:10.1097/PAS.0000000000000935. PMID 28877056.
- ↑ "N-terminal PAX8 polyclonal antibody shows cross-reactivity with N-terminal region of PAX5 and is responsible for reports of PAX8 positivity in malignant lymphomas". Mod. Pathol. 25 (2): 231–6. February 2012. doi:10.1038/modpathol.2011.162. PMID 22037256.
- ↑ Tacha, D.; Zhou, D.; Cheng, L. (Jul 2011). "Expression of PAX8 in normal and neoplastic tissues: a comprehensive immunohistochemical study.". Appl Immunohistochem Mol Morphol 19 (4): 293-9. doi:10.1097/PAI.0b013e3182025f66. PMID 21285870.