Difference between revisions of "Myoepithelial carcinoma"
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==Molecular== | ==Molecular== | ||
*Fusions with PLAG1.<ref name=pmid29084941>{{Cite journal | last1 = Dalin | first1 = MG. | last2 = Katabi | first2 = N. | last3 = Persson | first3 = M. | last4 = Lee | first4 = KW. | last5 = Makarov | first5 = V. | last6 = Desrichard | first6 = A. | last7 = Walsh | first7 = LA. | last8 = West | first8 = L. | last9 = Nadeem | first9 = Z. | title = Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions. | journal = Nat Commun | volume = 8 | issue = 1 | pages = 1197 | month = 10 | year = 2017 | doi = 10.1038/s41467-017-01178-z | PMID = 29084941 }}</ref> | *+/-Fusions with PLAG1 gene.<ref name=pmid29084941>{{Cite journal | last1 = Dalin | first1 = MG. | last2 = Katabi | first2 = N. | last3 = Persson | first3 = M. | last4 = Lee | first4 = KW. | last5 = Makarov | first5 = V. | last6 = Desrichard | first6 = A. | last7 = Walsh | first7 = LA. | last8 = West | first8 = L. | last9 = Nadeem | first9 = Z. | title = Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions. | journal = Nat Commun | volume = 8 | issue = 1 | pages = 1197 | month = 10 | year = 2017 | doi = 10.1038/s41467-017-01178-z | PMID = 29084941 }}</ref> | ||
*+/-EWSR1 gene rearrangement.<ref>{{Cite journal | last1 = Thway | first1 = K. | last2 = Bown | first2 = N. | last3 = Miah | first3 = A. | last4 = Turner | first4 = R. | last5 = Fisher | first5 = C. | title = Rhabdoid Variant of Myoepithelial Carcinoma, with EWSR1 Rearrangement: Expanding the Spectrum of EWSR1-Rearranged Myoepithelial Tumors. | journal = Head Neck Pathol | volume = 9 | issue = 2 | pages = 273-9 | month = Jun | year = 2015 | doi = 10.1007/s12105-014-0556-2 | PMID = 24993038 }}</ref> | |||
==See also== | ==See also== | ||
Revision as of 01:43, 19 March 2019
Myoepithelial carcinoma, abbreviated MECA a rare malignant salivary gland tumour.[1] It is the malignant counterpart of myoepithelioma.
General
- Rare.
Microscopic
Features:[2]
- Myoepithelial cells - may be cytologically very bland.
- Hypocellular centre (hyaline or myxoid) and hypercellular periphery.
- Pushing border ("expansile nodular lobulated pattern").
- No ductal structures.
Note:
- Overt features of malignancy (necrosis, nuclear atypia, infiltrative growth, proliferation) absent.
DDx:
IHC
- CAM5.2 +ve.
Molecular
See also
References
- ↑ Kong, M.; Drill, EN.; Morris, L.; West, L.; Klimstra, D.; Gonen, M.; Ghossein, R.; Katabi, N. (Jul 2015). "Prognostic factors in myoepithelial carcinoma of salivary glands: a clinicopathologic study of 48 cases.". Am J Surg Pathol 39 (7): 931-8. doi:10.1097/PAS.0000000000000452. PMID 25970687.
- ↑ Xu, B.; Mneimneh, W.; Torrence, DE.; Higgins, K.; Klimstra, D.; Ghossein, R.; Katabi, N. (Feb 2019). "Misinterpreted Myoepithelial Carcinoma of Salivary Gland: A Challenging and Potentially Significant Pitfall.". Am J Surg Pathol. doi:10.1097/PAS.0000000000001218. PMID 30789358.
- ↑ Dalin, MG.; Katabi, N.; Persson, M.; Lee, KW.; Makarov, V.; Desrichard, A.; Walsh, LA.; West, L. et al. (10 2017). "Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions.". Nat Commun 8 (1): 1197. doi:10.1038/s41467-017-01178-z. PMID 29084941.
- ↑ Thway, K.; Bown, N.; Miah, A.; Turner, R.; Fisher, C. (Jun 2015). "Rhabdoid Variant of Myoepithelial Carcinoma, with EWSR1 Rearrangement: Expanding the Spectrum of EWSR1-Rearranged Myoepithelial Tumors.". Head Neck Pathol 9 (2): 273-9. doi:10.1007/s12105-014-0556-2. PMID 24993038.