Gene fusion: Difference between revisions
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First fusion was described as BCR-ABL1 fusion in [[CML]]. Subsequently [[Imatinib]] was the first inhibitor targeting CML with BCR-ABL1 fusion. | First fusion was described as BCR-ABL1 fusion in [[CML]]. Subsequently [[Imatinib]] was the first inhibitor targeting CML with BCR-ABL1 fusion. | ||
==Methodology== | |||
Gene fusions can be detected by: | |||
* [[RT-PCR]] (fusion partners need to be known). | |||
* [[FISH]]. | |||
* RNA-Sequencing. | |||
* Whole Genome sequencing (WGS) (Comprehensive and unbiased, but short read length). | |||
* [[Immunohistochemistry]] (not suitable/available for all fusions). | |||