Difference between revisions of "NUT carcinoma"
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**Most common: t(15;19)(q13;p13.1) ''BRD4/NUT''.<ref>{{OMIM|608749}}</ref> | **Most common: t(15;19)(q13;p13.1) ''BRD4/NUT''.<ref>{{OMIM|608749}}</ref> | ||
***One source suggests it is: ''t(15;19)(q14;p13.1)''.<ref name=pmid18552174>{{Cite journal | last1 = French | first1 = CA. | title = Demystified molecular pathology of NUT midline carcinomas. | journal = J Clin Pathol | volume = 63 | issue = 6 | pages = 492-6 | month = Jun | year = 2010 | doi = 10.1136/jcp.2007.052902 | PMID = 18552174 }}</ref> | ***One source suggests it is: ''t(15;19)(q14;p13.1)''.<ref name=pmid18552174>{{Cite journal | last1 = French | first1 = CA. | title = Demystified molecular pathology of NUT midline carcinomas. | journal = J Clin Pathol | volume = 63 | issue = 6 | pages = 492-6 | month = Jun | year = 2010 | doi = 10.1136/jcp.2007.052902 | PMID = 18552174 }}</ref> | ||
==IHC== | |||
*CD34 +ve seen in ~50% of cases.<ref name=pmid21221870>{{Cite journal | last1 = Stelow | first1 = EB. | title = A review of NUT midline carcinoma. | journal = Head Neck Pathol | volume = 5 | issue = 1 | pages = 31-5 | month = Mar | year = 2011 | doi = 10.1007/s12105-010-0235-x | PMID = 21221870 }}</ref> | |||
==See also== | ==See also== | ||
Revision as of 19:21, 17 September 2018
| NUT carcinoma | |
|---|---|
| Diagnosis in short | |
 NUT midline carcinoma. H&E stain. | |
|
| |
| Synonyms | NUT carcinoma, carcinoma with t(15;19) translocation |
|
| |
| LM | cohesive malignant cells (poorly differentiated carcinoma), islands of well-differentiated squamous epithelium |
| LM DDx | Carcinoma ex pleomorphic adenoma, poorly differentiated carcinoma |
| Molecular | t(15;19) |
| Site | head and neck, mediastinum, usu. midline |
|
| |
| Prevalence | very rare |
| Prognosis | very poor |
NUT midline carcinoma, abbreviated NMC, is a rare tumour of the head and neck. The WHO calls this tumour carcinoma with t(15;19) translocation.[1] It is also known as NUT carcinoma.
General
- Not specific to any tissue type or organ.[2]
- Defined by mutation in NUT gene on chromosome 15.
- NUT = Nuclear protein in testis.[3]
Clinical:
- Usually midline - as the name of the tumour suggests.
- Case report of a NMC in the parotid gland.[4]
- Head, neck and mediastinum.[5]
- Very poor prognosis.[4]
Microscopic
- Poorly differentiated carcinoma.
- Cohesive malignant cells.
- Islands of well-differentiated squamous epithelium - key feature.
DDx:
- Carcinoma ex pleomorphic adenoma.
- Poorly differentiated carcinoma.
- SMARCB1-deficient sinonasal carcinoma.[6]
Images
NUT midline carcinoma - high mag. (WC)
NUT midline carcinoma - very high mag. (WC)
Molecular
- Rearrangement of the NUT gene.[2]
IHC
- CD34 +ve seen in ~50% of cases.[8]
See also
References
- ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 145. ISBN 978-0781765275.
- ↑ 2.0 2.1 2.2 French, CA. (Nov 2010). "NUT midline carcinoma.". Cancer Genet Cytogenet 203 (1): 16-20. doi:10.1016/j.cancergencyto.2010.06.007. PMID 20951314.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 608963
- ↑ 4.0 4.1 den Bakker, MA.; Beverloo, BH.; van den Heuvel-Eibrink, MM.; Meeuwis, CA.; Tan, LM.; Johnson, LA.; French, CA.; van Leenders, GJ. (Aug 2009). "NUT midline carcinoma of the parotid gland with mesenchymal differentiation.". Am J Surg Pathol 33 (8): 1253-8. doi:10.1097/PAS.0b013e3181abe120. PMID 19561446.
- ↑ 5.0 5.1 5.2 French, CA. (Jun 2010). "Demystified molecular pathology of NUT midline carcinomas.". J Clin Pathol 63 (6): 492-6. doi:10.1136/jcp.2007.052902. PMID 18552174.
- ↑ Bishop, JA.; Antonescu, CR.; Westra, WH. (Sep 2014). "SMARCB1 (INI-1)-deficient carcinomas of the sinonasal tract.". Am J Surg Pathol 38 (9): 1282-9. doi:10.1097/PAS.0000000000000285. PMID 25007146.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 608749
- ↑ Stelow, EB. (Mar 2011). "A review of NUT midline carcinoma.". Head Neck Pathol 5 (1): 31-5. doi:10.1007/s12105-010-0235-x. PMID 21221870.