Difference between revisions of "P53"
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| Subspecial = | | Subspecial = | ||
| Pattern = | | Pattern = | ||
| Positive = nuclear staining | | Positive = nuclear staining (>60% or completely negative - see ''interpretation'') | ||
| Negative = | | Negative = | ||
| Other = | | Other = | ||
Revision as of 15:29, 19 March 2018
| P53 | |
|---|---|
| Immunostain in short | |
 p53 staining in an anaplastic astrocytoma. | |
| Use | cancer versus benign, prognostication |
| Positive | nuclear staining (>60% or completely negative - see interpretation) |
p53 marks a tumour suppressor protein commonly implicated in cancer and a common immunostain.
Interpretation
- p53 may be one of the most misinterpreted stains.
- TP53 mutations are associated with >60% staining and no staining (0% of cell labelled).[1]
See also
References
- ↑ Yemelyanova, A.; Vang, R.; Kshirsagar, M.; Lu, D.; Marks, MA.; Shih, IeM.; Kurman, RJ. (Sep 2011). "Immunohistochemical staining patterns of p53 can serve as a surrogate marker for TP53 mutations in ovarian carcinoma: an immunohistochemical and nucleotide sequencing analysis.". Mod Pathol 24 (9): 1248-53. doi:10.1038/modpathol.2011.85. PMID 21552211.