Difference between revisions of "Rhabdomyoma"
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*May be seen in the context of [[tuberous sclerosis]]. | *May be seen in the context of [[tuberous sclerosis]]. | ||
*Rare benign mesenchymal tumour - may be seen in the [[head and neck pathology|head and neck]].<ref name=pmid16133368/> | *Rare benign mesenchymal tumour - may be seen in the [[head and neck pathology|head and neck]].<ref name=pmid16133368/> | ||
*Can cause death if in the [[cardiac tumours|heart]].<ref name=pmid23206573 >{{Cite journal | last1 = Neri | first1 = M. | last2 = Di Donato | first2 = S. | last3 = Maglietta | first3 = R. | last4 = Pomara | first4 = C. | last5 = Riezzo | first5 = I. | last6 = Turillazzi | first6 = E. | last7 = Fineschi | first7 = V. | title = Sudden death as presenting symptom caused by cardiac primary multicentric left ventricle rhabdomyoma, in an 11-month-old baby. An immunohistochemical study. | journal = Diagn Pathol | volume = 7 | issue = | pages = 169 | month = Dec | year = 2012 | doi = 10.1186/1746-1596-7-169 | PMID = 23206573 }}</ref> | |||
==Gross== | ==Gross== | ||
Revision as of 14:35, 4 September 2017
Rhabdomyoma a benign muscle tumour. Often seen in the context of tuberous sclerosis.
General
- May be seen in the context of tuberous sclerosis.
- Rare benign mesenchymal tumour - may be seen in the head and neck.[1]
- Can cause death if in the heart.[2]
Gross
- Solid, white/tan colour.
Image:
Microscopic
Features - cardiac:[3]
- Spider cells:
- Large polygonal cells (~10-20x RBC diameter):
- Abundant cytoplasm filled with glycogen.
- Large polygonal cells (~10-20x RBC diameter):
Note:
- Fetal rhabdomyomas may have pseudoepitheliomatous hyperplasia.[1]
DDx:
Images
Rhabdomyoma - low mag. (WC)
Rhabdomyoma - intermed. mag. (WC)
Rhabdomyoma - high mag. (WC)
Rhabdomyoma - very high mag. (WC)
Rhabdomyoma - desmin - intermed. mag. (WC)
Rhabdomyoma - desmin - high mag. (WC)
www
IHC
Features:[1]
- Desmin +ve.
- Myogoblin +ve.
- Actin +ve.
- S-100 -ve.
- Positive in granular cell tumour and hiberoma.
See also
References
- ↑ 1.0 1.1 1.2 Hansen, T.; Katenkamp, D. (Nov 2005). "Rhabdomyoma of the head and neck: morphology and differential diagnosis.". Virchows Arch 447 (5): 849-54. doi:10.1007/s00428-005-0038-8. PMID 16133368.
- ↑ Neri, M.; Di Donato, S.; Maglietta, R.; Pomara, C.; Riezzo, I.; Turillazzi, E.; Fineschi, V. (Dec 2012). "Sudden death as presenting symptom caused by cardiac primary multicentric left ventricle rhabdomyoma, in an 11-month-old baby. An immunohistochemical study.". Diagn Pathol 7: 169. doi:10.1186/1746-1596-7-169. PMID 23206573.
- ↑ URL: http://www.brown.edu/Courses/Digital_Path/systemic_path/cardio/rhabdomyoma.html. Accessed on: 19 October 2011.