Difference between revisions of "Atypical lobular hyperplasia"
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*[[Lobular carcinoma in situ]]. | *[[Lobular carcinoma in situ]]. | ||
*[[Lobular carcinoma]]. | *[[Lobular carcinoma]]. | ||
===Images=== | |||
<gallery> | |||
Image: Atypical lobular hyperplasia -- low mag.jpg | ALH - low mag. (WC) | |||
Image: Atypical lobular hyperplasia -- intermed mag.jpg | ALH - intermed. mag. (WC) | |||
Image: Atypical lobular hyperplasia -- high mag.jpg | ALH - high mag. (WC) | |||
Image: Atypical lobular hyperplasia - E-cadherin -- intermed mag.jpg | ALH - E-cadherin - intermed. mag. (WC) | |||
Image: Atypical lobular hyperplasia - E-cadherin -- high mag.jpg | ALH - E-cadherin - high mag. (WC) | |||
</gallery> | |||
<gallery> | |||
Image: Benign breast - E-cadherin -- intermed mag.jpg | Benign breast - E-cadherin - intermed. mag. (WC) | |||
Image: Benign breast - E-cadherin -- high mag.jpg | Benign breast - E-cadherin - high mag. (WC) | |||
Image: Benign breast - E-cadherin - alt -- high mag.jpg | Benign breast - E-cadherin - high mag. (WC) | |||
</gallery> | |||
==IHC== | ==IHC== | ||
Revision as of 04:53, 23 January 2017
Atypical lobular hyperplasia, abbreviated ALH, a pre-malignant change in the breast characterized by cellular proliferation and cellular dyscohesion.
It can be seen as the precursor to lobular carcinoma in situ, the precursor of lobular carcinoma.
General
- May occur with ductal involvement by cells of atypical lobular hyperplasia (abbreviated DIALH).[1]
- ALH with DIALH has a risk of developing breast cancer that is similar to LCIS.
Microscopic
Features:
- Extent criterium: <50% of terminal duct lobular unit (TDLU) is involved.
- See lobular carcinoma in situ for details.
DDx:
Images
ALH - low mag. (WC)
ALH - intermed. mag. (WC)
ALH - high mag. (WC)
ALH - E-cadherin - intermed. mag. (WC)
ALH - E-cadherin - high mag. (WC)
Benign breast - E-cadherin - intermed. mag. (WC)
Benign breast - E-cadherin - high mag. (WC)
Benign breast - E-cadherin - high mag. (WC)
IHC
- E-cadherin -ve or incomplete membrane staining.