Difference between revisions of "Placental alkaline phosphatase"
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{{ Infobox immunostain | |||
| Name = {{PAGENAME}} | |||
| Image = ITGCN and Sertoli cells only - PLAP -- high mag.jpg | |||
| Width = | |||
| Caption = PLAP in [[germ cell neoplasia in situ]] - left of image. (WC) | |||
| Abbrev = PLAP | |||
| Synonyms = | |||
| Similar = OCT4, OCT3/4 | |||
| Clones = | |||
| Use = [[germ cell tumours]] | |||
| Subspecial = [[genitourinary pathology]], [[gynecologic pathology]] | |||
| Pattern = membranous | |||
| Positive = [[germ cell neoplasia in situ]] (previously ITGCN), [[seminoma]], [[embryonal carcinoma]] | |||
| Negative = | |||
| Other = | |||
}} | |||
'''Placental alkaline phosphatase''', abbreviated '''PLAP''', is a common [[immunostain]] used for assessing suspected [[germ cell tumours]]. | '''Placental alkaline phosphatase''', abbreviated '''PLAP''', is a common [[immunostain]] used for assessing suspected [[germ cell tumours]]. | ||
Revision as of 19:03, 8 January 2017
| Placental alkaline phosphatase | |
|---|---|
| Immunostain in short | |
 PLAP in germ cell neoplasia in situ - left of image. (WC) | |
| Abbreviation | PLAP |
| Similar stains | OCT4, OCT3/4 |
| Use | germ cell tumours |
| Subspeciality | genitourinary pathology, gynecologic pathology |
| Normal staining pattern | membranous |
| Positive | germ cell neoplasia in situ (previously ITGCN), seminoma, embryonal carcinoma |
Placental alkaline phosphatase, abbreviated PLAP, is a common immunostain used for assessing suspected germ cell tumours.
It has largely been replaced by OCT4.
Negative
Positive
- Germ cell neoplasia in situ (intratubular germ cell neoplasia).[2]
- Seminoma.
- Embryonal carcinoma.
See also
References
- ↑ Hawkins, E.; Heifetz, SA.; Giller, R.; Cushing, B. (Apr 1997). "The prepubertal testis (prenatal and postnatal): its relationship to intratubular germ cell neoplasia: a combined Pediatric Oncology Group and Children's Cancer Study Group.". Hum Pathol 28 (4): 404-10. PMID 9104938.
- ↑ Schreiber, L.; Lifschitz-Mercer, B.; Paz, G.; Yavetz, H.; Elliott, DJ.; Kula, K.; Slowikowska-Hilczer, J.; Maymon, BB. (Jan 2003). "Double immunolabeling by the RBM and the PLAP markers for identifying intratubular (in situ) germ cell neoplasia of the testis.". Int J Surg Pathol 11 (1): 17-20. PMID 12598912.