Difference between revisions of "GATA3"
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*[[Chromophobe renal cell carcinoma]] ~50% of cases.<ref name=pmid24145643/> | *[[Chromophobe renal cell carcinoma]] ~50% of cases.<ref name=pmid24145643/> | ||
*[[Trophoblastic tumours]] +ve.<ref>{{Cite journal | last1 = Mirkovic | first1 = J. | last2 = Elias | first2 = K. | last3 = Drapkin | first3 = R. | last4 = Barletta | first4 = JA. | last5 = Quade | first5 = B. | last6 = Hirsch | first6 = MS. | title = GATA3 expression in gestational trophoblastic tissues and tumours. | journal = Histopathology | volume = 67 | issue = 5 | pages = 636-44 | month = Nov | year = 2015 | doi = 10.1111/his.12681 | PMID = 25753145 }}</ref> | *[[Trophoblastic tumours]] +ve.<ref>{{Cite journal | last1 = Mirkovic | first1 = J. | last2 = Elias | first2 = K. | last3 = Drapkin | first3 = R. | last4 = Barletta | first4 = JA. | last5 = Quade | first5 = B. | last6 = Hirsch | first6 = MS. | title = GATA3 expression in gestational trophoblastic tissues and tumours. | journal = Histopathology | volume = 67 | issue = 5 | pages = 636-44 | month = Nov | year = 2015 | doi = 10.1111/his.12681 | PMID = 25753145 }}</ref> | ||
*Parathyroid.<ref name=pmid25046229>{{Cite journal | last1 = Ordóñez | first1 = NG. | title = Value of GATA3 immunostaining in the diagnosis of parathyroid tumors. | journal = Appl Immunohistochem Mol Morphol | volume = 22 | issue = 10 | pages = 756-61 | month = | year = | doi = 10.1097/PAI.0000000000000007 | PMID = 25046229 }}</ref> | *Parathyroid - [[parathyroid hyperplasia]], [[parathyroid adenoma]], [[parathyroid carcinoma]].<ref name=pmid25046229>{{Cite journal | last1 = Ordóñez | first1 = NG. | title = Value of GATA3 immunostaining in the diagnosis of parathyroid tumors. | journal = Appl Immunohistochem Mol Morphol | volume = 22 | issue = 10 | pages = 756-61 | month = | year = | doi = 10.1097/PAI.0000000000000007 | PMID = 25046229 }}</ref> | ||
===Images=== | ===Images=== | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444740/figure/F1/ GATA3 nuclear staining - urothelial carcinoma (nih.gov)].<ref name=pmid22982890/> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444740/figure/F1/ GATA3 nuclear staining - urothelial carcinoma (nih.gov)].<ref name=pmid22982890/> | ||
Revision as of 13:35, 8 December 2016
| GATA3 | |
|---|---|
| Immunostain in short | |
 GATA3 staining in benign urothelium. | |
| Similar stains | thrombomodulin |
| Use | bladder versus prostate, bladder versus SCC |
| Subspeciality | Genitourinary pathology, Breast pathology |
| Normal staining pattern | nuclear |
| Positive | urothelial carcinoma, invasive ductal carcinoma of the breast, lobular breast carcinoma |
| Negative | prostatic carcinoma, squamous cell carcinoma of the lung |
GATA3 an immunostain that is increasingly used in genitourinary pathology.
Positive
- Urothelial carcinoma.[1]
- Breast carcinoma - more sensitive than GCDFP-15.[2]
- Chromophobe renal cell carcinoma ~50% of cases.[2]
- Trophoblastic tumours +ve.[4]
- Parathyroid - parathyroid hyperplasia, parathyroid adenoma, parathyroid carcinoma.[5]
Images
Negative
See also
References
- ↑ 1.0 1.1 1.2 Chang A, Amin A, Gabrielson E, et al. (October 2012). "Utility of GATA3 immunohistochemistry in differentiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine cervix, anus, and lung". Am. J. Surg. Pathol. 36 (10): 1472–6. doi:10.1097/PAS.0b013e318260cde7. PMC 3444740. PMID 22982890. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444740/.
- ↑ 2.0 2.1 Miettinen, M.; McCue, PA.; Sarlomo-Rikala, M.; Rys, J.; Czapiewski, P.; Wazny, K.; Langfort, R.; Waloszczyk, P. et al. (Jan 2014). "GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.". Am J Surg Pathol 38 (1): 13-22. doi:10.1097/PAS.0b013e3182a0218f. PMID 24145643.
- ↑ Ellis, CL.; Chang, AG.; Cimino-Mathews, A.; Argani, P.; Youssef, RF.; Kapur, P.; Montgomery, EA.; Epstein, JI. (Nov 2013). "GATA-3 immunohistochemistry in the differential diagnosis of adenocarcinoma of the urinary bladder.". Am J Surg Pathol 37 (11): 1756-60. doi:10.1097/PAS.0b013e31829cdba7. PMID 24061521.
- ↑ Mirkovic, J.; Elias, K.; Drapkin, R.; Barletta, JA.; Quade, B.; Hirsch, MS. (Nov 2015). "GATA3 expression in gestational trophoblastic tissues and tumours.". Histopathology 67 (5): 636-44. doi:10.1111/his.12681. PMID 25753145.
- ↑ Ordóñez, NG.. "Value of GATA3 immunostaining in the diagnosis of parathyroid tumors.". Appl Immunohistochem Mol Morphol 22 (10): 756-61. doi:10.1097/PAI.0000000000000007. PMID 25046229.