Difference between revisions of "Anal intraepithelial lesions"
(split out) |
|||
| Line 11: | Line 11: | ||
===Grading=== | ===Grading=== | ||
AIN is graded much like [[cervix|cervical intraepithelial neoplasia]]: | AIN is graded much like [[cervix|cervical intraepithelial neoplasia]]:<ref name=pmid25938361>{{Cite journal | last1 = Roberts | first1 = JM. | last2 = Jin | first2 = F. | last3 = Thurloe | first3 = JK. | last4 = Biro | first4 = C. | last5 = Poynten | first5 = IM. | last6 = Tabrizi | first6 = SN. | last7 = Fairley | first7 = CK. | last8 = Templeton | first8 = DJ. | last9 = Carr | first9 = AD. | title = High reproducibility of histological diagnosis of human papillomavirus-related intraepithelial lesions of the anal canal. | journal = Pathology | volume = 47 | issue = 4 | pages = 308-13 | month = Jun | year = 2015 | doi = 10.1097/PAT.0000000000000246 | PMID = 25938361 }}</ref> | ||
*High-grade anal intraepithelial neoplasia (HGAIN). | *High-grade anal intraepithelial neoplasia (HGAIN). | ||
*Low-grade anal intraepithelial neoplasia (LGAIN). | *Low-grade anal intraepithelial neoplasia (LGAIN). | ||
Revision as of 14:19, 6 May 2016
Anal intraepithelial neoplasia, abbreviated AIN, the precursor of anal squamous cell carcinoma.
General
- Precursor lesion of anal squamous cell carcinoma.
- Usually HPV associated.
- May be prevented by HPV vaccine.
Microscopic
DDx:
Grading
AIN is graded much like cervical intraepithelial neoplasia:[1]
- High-grade anal intraepithelial neoplasia (HGAIN).
- Low-grade anal intraepithelial neoplasia (LGAIN).
Sign out
ANAL CANAL, RIGHT UPPER QUADRANT, BIOPSY: - LOW-GRADE SQUAMOUS INTRAEPITHELIAL LESION (CONDYLOMA ACUMINATUM-LIKE).
ANAL CANAL, LEFT UPPER QUADRANT, BIOPSY: - LOW-GRADE SQUAMOUS INTRAEPITHELIAL LESION. - RECTAL MUCOSA WITHIN NORMAL LIMITS.
SKIN LESION, PERIANAL, BIOPSY: - ANAL INTRAEPITHELIAL NEOPLASIA 3 (SEVERE DYSPLASIA), WARTY-TYPE. - MARGIN POSITIVE FOR ANAL INTRAEPITHELIAL NEOPLASIA 3.
Micro
There is dysplastic squamous epithelium with coarse chromatin, nuclear hyperchromasia, nuclear enlargement, irregular nuclear membranes, and an increase nuclear-to-cytoplasmic ratio. Mitotic activity is abundant. Several atypical mitoses are identified.
The dysplastic squamous epithelium shows minimal maturation toward the surface (AIN 3). A sizable portion of the lesion show some maturation to the surface (AIN 2).
Inflammation at the dermal-epidermal interface is minimal and the dermal-epidermal interface is well-demarcated. Focal ulceration is present.
The margin of the biopsy has severely dysplastic epithelium (AIN 3).
See also
References
- ↑ Roberts, JM.; Jin, F.; Thurloe, JK.; Biro, C.; Poynten, IM.; Tabrizi, SN.; Fairley, CK.; Templeton, DJ. et al. (Jun 2015). "High reproducibility of histological diagnosis of human papillomavirus-related intraepithelial lesions of the anal canal.". Pathology 47 (4): 308-13. doi:10.1097/PAT.0000000000000246. PMID 25938361.
.