Difference between revisions of "Cytokeratin 5/6"
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==Use== | ==Use== | ||
* | *[[Prostatic adenocarcinoma]] versus [[high-grade prostatic intraepithelial neoplasia]] (HGPIN). | ||
**CK5/6 marks the basal cells: present in HGPIN, absent in cancer. | |||
*[[Urothelial cell carcinoma]] versus [[prostatic adenocarcinoma]]. | |||
**Positive in UCC, negative in prostate adenocarcinoma. | |||
==Positive== | |||
*[[Squamous cell carcinoma]]. | |||
*Benign prostate (basal cells).<ref name=pmid19605815>{{Cite journal | last1 = Trpkov | first1 = K. | last2 = Bartczak-McKay | first2 = J. | last3 = Yilmaz | first3 = A. | title = Usefulness of cytokeratin 5/6 and AMACR applied as double sequential immunostains for diagnostic assessment of problematic prostate specimens. | journal = Am J Clin Pathol | volume = 132 | issue = 2 | pages = 211-20; quiz 307 | month = Aug | year = 2009 | doi = 10.1309/AJCPGFJP83IXZEUR | PMID = 19605815 }}</ref> | |||
*[[Urothelial carcinoma]]. | |||
*[[Malignant mesothelioma]].<ref name=pmid18318582>{{cite journal |author=Marchevsky AM |title=Application of immunohistochemistry to the diagnosis of malignant mesothelioma |journal=Arch. Pathol. Lab. Med. |volume=132 |issue=3 |pages=397-401 |year=2008 |month=March |pmid=18318582 |doi= |url=http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0003-9985&volume=132&page=397}}</ref> | |||
==Negative== | |||
*[[Adenocarcinoma of the lung]].<ref name=pmid18318582>{{cite journal |author=Marchevsky AM |title=Application of immunohistochemistry to the diagnosis of malignant mesothelioma |journal=Arch. Pathol. Lab. Med. |volume=132 |issue=3 |pages=397-401 |year=2008 |month=March |pmid=18318582 |doi= |url=http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0003-9985&volume=132&page=397}}</ref> | |||
==See also== | ==See also== | ||
Revision as of 20:50, 5 May 2016
Cytokeratin 5/6, abbreviated CK/5/6, is a common immunostain.
Use
- Prostatic adenocarcinoma versus high-grade prostatic intraepithelial neoplasia (HGPIN).
- CK5/6 marks the basal cells: present in HGPIN, absent in cancer.
- Urothelial cell carcinoma versus prostatic adenocarcinoma.
- Positive in UCC, negative in prostate adenocarcinoma.
Positive
- Squamous cell carcinoma.
- Benign prostate (basal cells).[1]
- Urothelial carcinoma.
- Malignant mesothelioma.[2]
Negative
See also
- ↑ Trpkov, K.; Bartczak-McKay, J.; Yilmaz, A. (Aug 2009). "Usefulness of cytokeratin 5/6 and AMACR applied as double sequential immunostains for diagnostic assessment of problematic prostate specimens.". Am J Clin Pathol 132 (2): 211-20; quiz 307. doi:10.1309/AJCPGFJP83IXZEUR. PMID 19605815.
- ↑ 2.0 2.1 Marchevsky AM (March 2008). "Application of immunohistochemistry to the diagnosis of malignant mesothelioma". Arch. Pathol. Lab. Med. 132 (3): 397-401. PMID 18318582. http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0003-9985&volume=132&page=397.