Difference between revisions of "Intramucosal colorectal carcinoma"
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**This is different than elsewhere in the GI tract, where cancer is defined by invasion through the basement membrane, i.e. into the lamina propria. | **This is different than elsewhere in the GI tract, where cancer is defined by invasion through the basement membrane, i.e. into the lamina propria. | ||
**Rationale: atypical (cancer-like) cells in lamina propria do ''not'' have [[metastasis|metastatic]] potential as there are no lymphatics in the colorectal lamina propria.<ref>{{Cite journal | last1 = Lewin | first1 = MR. | last2 = Fenton | first2 = H. | last3 = Burkart | first3 = AL. | last4 = Sheridan | first4 = T. | last5 = Abu-Alfa | first5 = AK. | last6 = Montgomery | first6 = EA. | title = Poorly differentiated colorectal carcinoma with invasion restricted to lamina propria (intramucosal carcinoma): a follow-up study of 15 cases. | journal = Am J Surg Pathol | volume = 31 | issue = 12 | pages = 1882-6 | month = Dec | year = 2007 | doi = 10.1097/PAS.0b013e318057fac2 | PMID = 18043043 }}</ref> | **Rationale: atypical (cancer-like) cells in lamina propria do ''not'' have [[metastasis|metastatic]] potential as there are no lymphatics in the colorectal lamina propria.<ref>{{Cite journal | last1 = Lewin | first1 = MR. | last2 = Fenton | first2 = H. | last3 = Burkart | first3 = AL. | last4 = Sheridan | first4 = T. | last5 = Abu-Alfa | first5 = AK. | last6 = Montgomery | first6 = EA. | title = Poorly differentiated colorectal carcinoma with invasion restricted to lamina propria (intramucosal carcinoma): a follow-up study of 15 cases. | journal = Am J Surg Pathol | volume = 31 | issue = 12 | pages = 1882-6 | month = Dec | year = 2007 | doi = 10.1097/PAS.0b013e318057fac2 | PMID = 18043043 }}</ref> | ||
Note: | |||
*If one want to differentiate ''adenocarcinoma in situ'' and ''high-grade dysplasia'': | |||
**''Adenocarcinoma in situ'' has ''invasion into the lamina propria'' and ''high-grade dysplasia'' does ''not'' have lamina propria invasion. Thus, the difference amounts to seeing a [[desmoplastic stroma]] or infiltrative cells; if one of these is present it is ''adenocarcinoma in situ'', if both are ''not'' it is ''dysplasia''. | |||
==See also== | ==See also== | ||
Revision as of 01:17, 19 April 2016
Intramucosal colorectal carcinoma is a confusing term for high grade (colorectal) dysplasia that should be avoided.[1]
Intramucosal rectal carcinoma, intramucosal colonic carcinoma, intramucosal colonic adenocarcinoma, intramucosal rectal adenocarcinoma and colorectal adenocarcinoma in situ redirect here.
Background
- Colorectal adenocarcinoma is defined by invasion into the submucosa.
- This is different than elsewhere in the GI tract, where cancer is defined by invasion through the basement membrane, i.e. into the lamina propria.
- Rationale: atypical (cancer-like) cells in lamina propria do not have metastatic potential as there are no lymphatics in the colorectal lamina propria.[2]
Note:
- If one want to differentiate adenocarcinoma in situ and high-grade dysplasia:
- Adenocarcinoma in situ has invasion into the lamina propria and high-grade dysplasia does not have lamina propria invasion. Thus, the difference amounts to seeing a desmoplastic stroma or infiltrative cells; if one of these is present it is adenocarcinoma in situ, if both are not it is dysplasia.
See also
References
- ↑ Fleming, M.; Ravula, S.; Tatishchev, SF.; Wang, HL. (Sep 2012). "Colorectal carcinoma: Pathologic aspects.". J Gastrointest Oncol 3 (3): 153-73. doi:10.3978/j.issn.2078-6891.2012.030. PMID 22943008.
- ↑ Lewin, MR.; Fenton, H.; Burkart, AL.; Sheridan, T.; Abu-Alfa, AK.; Montgomery, EA. (Dec 2007). "Poorly differentiated colorectal carcinoma with invasion restricted to lamina propria (intramucosal carcinoma): a follow-up study of 15 cases.". Am J Surg Pathol 31 (12): 1882-6. doi:10.1097/PAS.0b013e318057fac2. PMID 18043043.