Difference between revisions of "Oncocytoma of the salivary gland"

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'''Oncocytoma of the salivary gland''' is a rare benign tumour of the [[salivary glands]].
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Parotid_gland_oncocytoma_-_very_high_mag.jpg
| Width      =
| Caption    = Salivary gland oncocytoma. [[H&E stain]]. (WC/Nephron)
| Synonyms  = salivary gland oncocytoma
| Micro      = abundant eosinophilic cytoplasm; architecture: solid, trabecular or duct-like
| Subtypes  =
| LMDDx      = [[acinic cell carcinoma]], metastatic [[renal cell carcinoma]], oncocytic carcinoma
| Stains    =
| IHC        = p63 +ve
| EM        = increased numbers of mitochondria
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Staging    =
| Site      = [[salivary gland]]
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = very rare
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign
| Other      =
| ClinDDx    = other salivary gland tumours
| Tx        =
}}
'''Oncocytoma of the salivary gland''' (also '''salivary gland oncocytoma''') is a rare benign tumour of the [[salivary glands]].


==General==
==General==
*No risk of malignant transformation.
*No risk of malignant transformation.
*Rare ~20 reported in literature.<ref>{{cite journal |author=Uzunkulaoğlu H, Yazici H, Can IH, Doğan S, Uzunkulaoğlu T |title=Bilateral oncocytoma in the parotid gland |journal=J Craniofac Surg |volume=23 |issue=3 |pages=e246–7 |year=2012 |month=May |pmid=22627459 |doi=10.1097/SCS.0b013e31824dfccd |url=}}</ref>
*Rare ~20 reported in literature.<ref name=pmid22627459>{{cite journal |author=Uzunkulaoğlu H, Yazici H, Can IH, Doğan S, Uzunkulaoğlu T |title=Bilateral oncocytoma in the parotid gland |journal=J Craniofac Surg |volume=23 |issue=3 |pages=e246–7 |year=2012 |month=May |pmid=22627459 |doi=10.1097/SCS.0b013e31824dfccd |url=}}</ref>
*Thought to be ~1% of all salivary gland tumours.
*Thought to be ~1% of all salivary gland tumours.
*Typical age: 60s-80s.
*Typical age: 60s-80s.
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Features:
Features:
*Like [[oncocytoma]]s elsewhere.  
*Like [[oncocytoma]]s elsewhere.  
**Eosinophilic cytoplasm (on [[H&E stain]]).
**Abundant eosinophilic cytoplasm (on [[H&E stain]]).
***Due to increased number of mitochrondria.
***Due to increased number of mitochrondria.
**Fine capillaries.
**Fine capillaries.
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DDx:
DDx:
*[[Acinic cell carcinoma]].
*[[Acinic cell carcinoma]].
*Metastatic [[renal cell carcinoma]] - esp. [[chromophobe renal cell carcinoma]].
*Oncocytic carcinoma.


===Images===
===Images===

Revision as of 15:45, 8 April 2016

Oncocytoma of the salivary gland
Diagnosis in short

Salivary gland oncocytoma. H&E stain. (WC/Nephron)
Synonyms salivary gland oncocytoma
LM abundant eosinophilic cytoplasm; architecture: solid, trabecular or duct-like
LM DDx acinic cell carcinoma, metastatic renal cell carcinoma, oncocytic carcinoma
IHC p63 +ve
EM increased numbers of mitochondria
Site salivary gland
Prevalence very rare
Prognosis benign
Clin. DDx other salivary gland tumours

Oncocytoma of the salivary gland (also salivary gland oncocytoma) is a rare benign tumour of the salivary glands.

General

  • No risk of malignant transformation.
  • Rare ~20 reported in literature.[1]
  • Thought to be ~1% of all salivary gland tumours.
  • Typical age: 60s-80s.
  • Associated with radiation exposure.
  • Major salivary glands - usually parotid gland.[2]

Gross

  • Golden brown appearance.

Image

  • Salivary gland oncocytoma (WC/euthman)

Microscopic

Features:

  • Like oncocytomas elsewhere.
    • Abundant eosinophilic cytoplasm (on H&E stain).
      • Due to increased number of mitochrondria.
    • Fine capillaries.
  • Architecture: solid sheets, trabeculae or duct-like structure.[2]

Notes:

  • May have clear cell change.
  • Multiple small incidental lesions = oncocytosis - not oncocytoma.

DDx:

Images

www:

  • Parotid gland oncocytoma - intermed. mag. (WC/Nephron)

  • Parotid gland oncocytoma - high mag. (WC/Nephron)

  • Parotid gland oncocytoma - very high mag. (WC/Nephron)

IHC

  • p63 +ve[3] focally in nucleus.

See also

References

  1. ↑ Uzunkulaoğlu H, Yazici H, Can IH, Doğan S, Uzunkulaoğlu T (May 2012). "Bilateral oncocytoma in the parotid gland". J Craniofac Surg 23 (3): e246–7. doi:10.1097/SCS.0b013e31824dfccd. PMID 22627459.
  2. ↑ 2.0 2.1 Zhou, CX.; Gao, Y. (Dec 2009). "Oncocytoma of the salivary glands: a clinicopathologic and immunohistochemical study.". Oral Oncol 45 (12): e232-8. doi:10.1016/j.oraloncology.2009.08.004. PMID 19796983.
  3. ↑ 3.0 3.1 McHugh, JB.; Hoschar, AP.; Dvorakova, M.; Parwani, AV.; Barnes, EL.; Seethala, RR. (Dec 2007). "p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma.". Head Neck Pathol 1 (2): 123-31. doi:10.1007/s12105-007-0031-4. PMC 2807526. PMID 20614263. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807526/.
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