Difference between revisions of "Chromosomal translocations"

Revision as of 19:55, 7 March 2011

Chromosomal translocations, also translocations, may be characteristic of a tumour or simply narrow down the diagnosis to a set of tumours.

The key point is:

One should be aware of the existence of specific (i.e. diagnostic/near diagnostic) translocations and translocations which significantly narrow down the diagnosis -- which are available to (clinical) pathologists.

Translocation are often a subject of pimping and show-up on examinations.

Translocation	Genes	Tumour(s)	Reference
t(12;16)	FUS/ATF1	angiomatoid fibrous histiocytoma	^[1]
t(12;22)	EWS/ATF1	angiomatoid fibrous histiocytoma	^[1]
t(12;16)	EWS/CHOP	myxoid liposarcoma	^[1]
t(16;22)	EWS/ATF1	myxoid liposarcoma	^[1]
t(12;22)	EWS/ATF1	clear cell sarcoma	^[1]
t(21;22)	EWS/ATF1	Ewing sarcoma	^[1]
t(12;21)	FUS/ERG	Ewing sarcoma	^[1]
t(12;21)	FUS/ERG	acute myeloid leukemia	^[1]

@@ Line 1: / Line 1: @@
-'''Chromosomal translocations''', also '''translocations''', may be characteristic of a tumour or simply narrow down the diagnosis to a set of tumours.  They are often a subject of pimping and show-up on examinations.
+'''Chromosomal translocations''', also '''translocations''', may be characteristic of a tumour or simply narrow down the diagnosis to a set of tumours.
+==Key point==
 The key point is:
-*One should be aware of the existence of (specific) translocations and translocations which significantly narrow down the diagnosis -- which are available (for clinical pathology).
+*One should be aware of the existence of specific (i.e. diagnostic/near diagnostic) translocations and translocations which significantly narrow down the diagnosis -- which are available to (clinical) pathologists.
+===Unfortunate reality of residency===
+Translocation are often a subject of pimping and show-up on examinations.
+==List of translocations==
 {| class="wikitable"